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Review
. 2023 Aug 15:246:125669.
doi: 10.1016/j.ijbiomac.2023.125669. Epub 2023 Jul 3.

Chitosan and its derivatives in 3D/4D (bio) printing for tissue engineering and drug delivery applications

Tarun Agarwal  1 , Irene Chiesa  2 , Marco Costantini  3 , Anna Lopamarda  2 , Maria Celeste Tirelli  4 , Om Prakash Borra  5 , Subhash Venkata Sai Varshapally  5 , Yanamadala Ashwin Vijay Kumar  5 , G Koteswara Reddy  5 , Carmelo De Maria  6 , Lijie Grace Zhang  7 , Tapas Kumar Maiti  8
Affiliations
Review

Chitosan and its derivatives in 3D/4D (bio) printing for tissue engineering and drug delivery applications

Tarun Agarwal et al. Int J Biol Macromol. .

Abstract

Tissue engineering research has undergone to a revolutionary improvement, thanks to technological advancements, such as the introduction of bioprinting technologies. The ability to develop suitable customized biomaterial inks/bioinks, with excellent printability and ability to promote cell proliferation and function, has a deep impact on such improvements. In this context, printing inks based on chitosan and its derivatives have been instrumental. Thus, the current review aims at providing a comprehensive overview on chitosan-based materials as suitable inks for 3D/4D (bio)printing and their applicability in creating advanced drug delivery platforms and tissue engineered constructs. Furthermore, relevant strategies to improve the mechanical and biological performances of this biomaterial are also highlighted.

Keywords: 3D/4D printing; Bioinks; Chitosan; Drug delivery; Tissue engineering.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.