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Comment
. 2023 Jul;619(7968):E9-E18.
doi: 10.1038/s41586-023-06269-0. Epub 2023 Jul 5.

DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition

Eikan Mishima #  1   2 , Toshitaka Nakamura #  1 , Jiashuo Zheng #  1 , Weijia Zhang  1 , André Santos Dias Mourão  3 , Peter Sennhenn  4 , Marcus Conrad  5
Affiliations
Comment

DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition

Eikan Mishima et al. Nature. 2023 Jul.
No abstract available

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References

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    1. Mao, C. et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature 593, 586–590 (2021). - DOI - PubMed - PMC
    1. Doll, S. et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575, 693–698 (2019). - DOI - PubMed
    1. Zhang, L. et al. Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: current development and future perspectives. Eur. J. Med. Chem. 232, 114176 (2022). - DOI - PubMed
    1. Baumgartner, R. et al. Dual binding mode of a novel series of DHODH inhibitors. J. Med. Chem. 49, 1239–1247 (2006). - DOI - PubMed

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