Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jul 3;6(7):e1385.
doi: 10.1002/hsr2.1385. eCollection 2023 Jul.

Association of time-restricted feeding, arterial age, and arterial stiffness in adults with metabolic syndrome

Maryam Alinezhad-Namaghi  1   2 , Saeid Eslami  3 , Mohsen Nematy  2   4 , Reza Rezvani  2 , Adeleh Khoshnasab  2 , Shokoofeh Bonakdaran  4 , Elena Philippou  5   6 , Abdolreza Norouzy  2
Affiliations

Association of time-restricted feeding, arterial age, and arterial stiffness in adults with metabolic syndrome

Maryam Alinezhad-Namaghi et al. Health Sci Rep. .

Abstract

Background: Time-restricted feeding (TRF) is a kind of intermittent fasting defined as eating and drinking only during a certain number of hours in a day. It has been suggested that intermittent fasting may improve cardiovascular risk factors. This study evaluated the association of TRF and arterial stiffness, using pulse wave velocity (PWV), pulse wave analysis, and arterial age in metabolic syndrome participants.

Methods: A cohort study was carried out among metabolic syndrome adults who were followed over the Ramadan fasting period (used as a model of TRF since food was only allowed for about 8 h/day). The subjects were divided into Ramadan fasting and Ramadan nonfasting groups. The aortic PWV and central aortic pressure waveform were measured. Central systolic pressure, central pulse pressure, and indices of arterial compliance, such as augmentation pressure and augmentation index (AIx), were determined from waveform analysis.

Results: Ninety-five adults (31.57% female, age: 45.46 ± 9.10 years) with metabolic syndrome (based on the International Diabetes Federation definition) participated in this study. Ramadan fasting and Ramadan nonfasting groups were including 80 and 15 individuals respectively. A significant reduction was seen in PWV (0.29 m/s), central systolic pressure (4.03 mmHg), central pulse pressure (2.43 mmHg), central augmentation pressure (1.88 mmHg), and central AIx (2.47) in the Ramadan fasting group (p = 0.014, p < 0.001, p = 0.001, p = 0.003, and p = 0.036 respectively). There were no significant changes in these indices among the Ramadan nonfasting group.

Conclusions: This study suggested that TRF reduces arterial age and improves arterial stiffness among people with metabolic syndrome. This might be considered a beneficial nutrition strategy for extending healthspan (and perhaps longevity).

Keywords: arterial age; arterial stiffness; metabolic syndrome; pulse wave velocity; time‐restricted feeding.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Effect of intermittent fasting on arterial stiffness in adults with metabolic syndrome (N = 95).
See this image and copyright information in PMC

References

    1. United Nations, Department of Economic and Social Affairs, Population Division . World population prospects 2019: ten key findings. 2019.
    1. World Health Organisation . Cardiovascular diseases (CVDs) fact sheet [updated 11 June 2021]. Accessed February 9, 2022. http://www.who.int/mediacentre/factsheets/fs317/en/
    1. Fontana L, Partridge L, Longo VD. Extending healthy life span‐‐from yeast to humans. Science. 2010;328(5976):321‐326. - PMC - PubMed
    1. Longo VD, Antebi A, Bartke A, et al. Interventions to slow aging in humans: are we ready? Aging cell. 2015;14(4):497‐510. - PMC - PubMed
    1. Azizi F, Hadaegh F, Khalili D, et al. Appropriate definition of metabolic syndrome among Iranian adults: report of the Iranian national committee of obesity. Arch Iran Med. 2010;13(5):426‐428. - PubMed

LinkOut - more resources