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. 2023 Oct;16(5):480-482.
doi: 10.1161/CIRCGEN.122.004047. Epub 2023 Jul 6.

Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults

Rodrigo Guarischi-Sousa  1 , Elias Salfati  2 , Pik Fang Kho  1 , Kruthika R Iyer  1 , Austin T Hilliard  3 , David M Herrington  4 , Philip S Tsao  1   5   3 , Shoa L Clarke #  1   6   3 , Themistocles L Assimes #  1   7   5   3
Affiliations

Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults

Rodrigo Guarischi-Sousa et al. Circ Genom Precis Med. 2023 Oct.
No abstract available

Keywords: coronary artery disease; genetic predisposition to disease; genetic testing; low density lipoprotein; precision medicine; primary prevention; young adults.

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Conflict of interest statement

Disclosures None.

Figures

Figure.
Figure.
Association between contemporary polygenic scores for traits related to coronary artery disease and the presence of right coronary artery atherosclerosis in adolescents and young adults. Odds ratio and 95% CIs per 1 SD increase in polygenic risk score for the presence of raised lesions among White (A) and Black (B) subjects in the Pathobiological Determinants of Atherosclerosis in Youth study. Polygenic scores (PGSs) are named as per the PGS catalog, but associations are classified into those related to adiposity, coronary artery disease (CAD), dysglycemia, dyslipidemia, and hypertension. P values shown are unadjusted with an asterisk indicating significance at a false discovery rate of 0.05. C, Prevalence of raised lesions among all White subjects (left) and burden of raised lesion among White cases only (right) by PGS quintiles for the CAD and LDL cholesterol PGSs. BMI indicates body mass index; fat %, body fat percentage; GWS, genome-wide significant variants; Ins, insulin; LDL, low-density lipoprotein cholesterol; Lp(a), lipoprotein a; P. Reg., penalized regression; P+T, pruning and thresholding; SBP, systolic blood pressure; Trig, triglycerides; and T2D, type 2 diabetes.
See this image and copyright information in PMC

References

    1. Strong JP, Malcom GT, McMahan CA, Tracy RE, Newman WP, 3rd, Herderick EE, Cornhill JF. Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study. JAMA. 1999;281:727–735. doi: 10.1001/jama.281.8.727 - PubMed
    1. Salfati E, Nandkeolyar S, Fortmann SP, Sidney S, Hlatky MA, Quertermous T, Go AS, Iribarren C, Herrington DM, Goldstein BA, et al. . Susceptibility loci for clinical coronary artery disease and subclinical coronary atherosclerosis throughout the life-course. Circ Cardiovasc Genet. 2015;8:803–811. doi: 10.1161/CIRCGENETICS.114.001071 - PMC - PubMed
    1. Lambert SA, Gil L, Jupp S, Ritchie SC, Xu Y, Buniello A, McMahon A, Abraham G, Chapman M, Parkinson H, et al. . The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation. Nat Genet. 2021;53:420–425. doi: 10.1038/s41588-021-00783-5 - PMC - PubMed
    1. Graham SE, Clarke SL, Wu KH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, et al. ; VA Million Veteran Program. The power of genetic diversity in genome-wide association studies of lipids. Nature. 2021;600:675–679. doi: 10.1038/s41586-021-04064-3 - PMC - PubMed
    1. Wu H, Forgetta V, Zhou S, Bhatnagar SR, Pare G, Richards JB. Polygenic risk score for low-density lipoprotein cholesterol is associated with risk of ischemic heart disease and enriches for individuals with familial hypercholesterolemia. Circ Genom Precis Med. 2021;14:e003106. doi: 10.1161/CIRCGEN.120.003106 - PubMed

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