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. 2023 Nov;43(11):2005-2007.
doi: 10.1177/0271678X231187174. Epub 2023 Jul 6.

Evolution of endovascular therapy trials for basilar artery occlusion

Thanh N Nguyen  1 , Marc Fisher  2 , Wouter J Schonewille  3
Affiliations

Evolution of endovascular therapy trials for basilar artery occlusion

Thanh N Nguyen et al. J Cereb Blood Flow Metab. 2023 Nov.

Abstract

Basilar artery occlusion (BAO) is an uncommon event, and leads to poor outcome in an estimated 60 to 80% of patients. Two early randomized trials, BASICS and BEST demonstrated equivocal benefit of endovascular therapy (EVT) compared to medical management. These trials helped in forming the design, sample size and eligibility criteria for the subsequent two trials, ATTENTION and BAOCHE which demonstrated superiority of EVT over medical management. In this commentary, we look at the evolution of how early BAO studies formed the building blocks for successive BAO trials, review lessons learned, and opportunities for future research.

Keywords: Basilar artery occlusion; endovascular therapy; large vessel occlusion; posterior circulation; randomized trials.

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Conflict of interest statement

Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: T. Nguyen reports advisory board for Idorsia. W. Schonewille reports PI of BASICS trial.

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