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Randomized Controlled Trial
. 2023;55(2):103-108.
doi: 10.5114/ait.2023.129276.

Comparison of intranasal dexmedetomidine-midazolam, dexmedetomidine-ketamine, and midazolam-ketamine for premedication in paediatric patients: a double-blinded randomized trial

Vaishnavi Bd  1 , Shilpa Goyal  1 , Ankur Sharma  1 , Nikhil Kothari  1 , Narendra Kaloria  2 , Priyanka Sethi  1 , Pradeep Bhatia  1
Affiliations
Randomized Controlled Trial

Comparison of intranasal dexmedetomidine-midazolam, dexmedetomidine-ketamine, and midazolam-ketamine for premedication in paediatric patients: a double-blinded randomized trial

Vaishnavi Bd et al. Anaesthesiol Intensive Ther. 2023.

Abstract

Background: Paediatric patients are a population with a high level of anxiety. The prevention of perioperative stress in a frightened child is important to render the child calm and cooperative for smoother induction. Intranasal premedication is easy and safe, and the drug is rapidly absorbed into the systemic circulation, ensuring early onset of sedation in children and good effectiveness.

Methods: 150 patients in the age group 2-4 years, ASA class I, undergoing elective surgical procedures were enrolled. The patients were randomly divided into 3 groups: a DM group (receiving intranasal dexmedetomidine 1 µg kg -1 and midazolam 0.12 mg kg -1 ), a DK group (receiving intranasal dexmedetomidine 1 µg kg -1 and keta-mine 2 mg kg -1 ), and an MK group (receiving intranasal midazolam 0.12 mg kg -1 and ketamine 2 mg kg -1 ). After 30 minutes of administration of the drugs, the patients were assessed for parent separation anxiety, sedation, ease of IV cannulation, and mask acceptance.

Results: The comparison among the 3 groups showed a statistically significant difference for ease of IV cannulation and mask acceptance at 30 minutes, with a P -value of 0.010 with CI of 0.0-0.02, and P -value 0.007 with CI 0.0-0.02, respectively. The parent separation anxiety and sedation score at 30 minutes was statistically insignificant with a P -value of 0.82 with CI of 0.03-0.14 and P -value 0.631 with CI of 0.38-0.58, respectively.

Conclusions: The combination of midazolam and ketamine had a better clinical profile for premedication as compared to other combination drugs used in our study in terms of IV cannulation and acceptance of masks with a comparable decrease in separation anxiety from parents and adequate sedation.

Keywords: children; dexmedetomidine; ketamine; midazolam; separation anxiety.

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Conflict of interest statement

none.

Figures

FIGURE 1
FIGURE 1
Consort diagram
FIGURE 2
FIGURE 2
Ease of intravenous cannulation at 30 minutes. The ease of IV cannulation at 30 minutes, as shown in the above figure, was statistically significant, with a median of 2 and a P-value of 0.010, with the MK group demonstrating more satisfactory results than the DK and DM groups
FIGURE 3
FIGURE 3
Mask acceptance at 30 minutes. The mask acceptance at 30 minutes, as shown in the above figure, was statistically significant, with a median value of 3 and a P-value of 0.007, with the MK group demonstrating more satisfactory results than the DK and DM groups
FIGURE 4
FIGURE 4
Parent separation score at 30 minutes. The parent separation score at 30 minutes, as shown in the above figure, was similar in all the 3 groups, with median value of 2 and a P-value of 0.82
See this image and copyright information in PMC

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