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. 2023:2684:3-25.
doi: 10.1007/978-1-0716-3291-8_1.

Scoring Systems for Immunohistochemistry in Urothelial Carcinoma

Mark-Sebastian Bösherz  1 , Iryna V Samarska  2 , Nadine T Gaisa  3   4
Affiliations

Scoring Systems for Immunohistochemistry in Urothelial Carcinoma

Mark-Sebastian Bösherz et al. Methods Mol Biol. 2023.

Abstract

Immunohistochemistry is widely used in diagnostic and scientific analysis of urothelial carcinoma. Objective interpretation of staining results is mandatory for accuracy and comparability in diagnostic and therapeutic patient care as well as research.Herein we summarize and explain standardized microscopic evaluation and scoring approaches for immunohistochemical stainings. We focus on commonly used and generally feasible approaches for different cellular compartments and comment on their utility in diagnostics and research practice.

Keywords: Immunohistochemistry; Scoring; Therapeutic markers; Tumor markers; Urothelial carcinoma.

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References

    1. Magaki S, Hojat SA, Wei B et al (2019) An introduction to the performance of immunohistochemistry. Methods Mol Biol 1897:289–298. https://doi.org/10.1007/978-1-4939-8935-5_25 - DOI - PubMed - PMC
    1. Sukswai N, Khoury JD (2019) Immunohistochemistry innovations for diagnosis and tissue-based biomarker detection. Curr Hematol Malig Rep 14(5):368–375. https://doi.org/10.1007/s11899-019-00533-9 - DOI - PubMed
    1. Amin MB, Trpkov K, Lopez-Beltran A et al (2014) Best practices recommendations in the application of immunohistochemistry in the bladder lesions: report from the International Society of Urologic Pathology consensus conference. Am J Surg Pathol 38(8):e20–e34. https://doi.org/10.1097/PAS.0000000000000240 - DOI - PubMed
    1. Bellizzi AM (2020) An algorithmic immunohistochemical approach to define tumor type and assign site of origin. Adv Anat Pathol 27(3):114–163. https://doi.org/10.1097/PAP.0000000000000256 - DOI - PubMed - PMC
    1. Lopez-Beltran A, Marques RC, Montironi R et al (2015) Dysplasia and carcinoma in situ of the urinary bladder. Anal Quant Cytopathol Histpathol 37(1):29–38 - PubMed

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