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Meta-Analysis
. 2023 Dec 1;36(4):202-218.
doi: 10.1097/WNN.0000000000000348.

Can the Ability to Recognize Facial Emotions in Individuals With Neurodegenerative Disease be Improved? A Systematic Review and Meta-analysis

Naz Mirzai  1   2 , Kévin Polet  1 , Adeline Morisot  1   3 , Solange Hesse  1 , Alain Pesce  4 , Sandrine Louchart de la Chapelle  1 , Galina Iakimova  2
Affiliations
Meta-Analysis

Can the Ability to Recognize Facial Emotions in Individuals With Neurodegenerative Disease be Improved? A Systematic Review and Meta-analysis

Naz Mirzai et al. Cogn Behav Neurol. .

Abstract

Background: Facial emotion recognition (FER) is commonly impaired in individuals with neurodegenerative disease (NDD). This impairment has been linked to an increase in behavioral disorders and caregiver burden.

Objective: To identify interventions targeting the improvement of FER ability in individuals with NDD and investigate the magnitude of the efficacy of the interventions. We also wanted to explore the duration of the effects of the intervention and their possible impacts on behavioral and psychological symptoms of dementia and caregiver burden.

Method: We included 15 studies with 604 individuals who had been diagnosed with NDD. The identified interventions were categorized into three types of approach (cognitive, neurostimulation, and pharmacological) as well as a combined approach (neurostimulation with pharmacological).

Results: The three types of approaches pooled together had a significant large effect size for FER ability improvement (standard mean difference: 1.21, 95% CI = 0.11, 2.31, z = 2.15, P = 0.03). The improvement lasted post intervention, in tandem with a decrease in behavioral disorders and caregiver burden.

Conclusion: A combination of different approaches for FER ability improvement may be beneficial for individuals with NDD and their caregivers.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
PRISMA flow diagram of the selection procedure. FER = facial emotion recognition. PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
FIGURE 2
FIGURE 2
Forest plot of the overall intervention approaches with FER as the outcome variable. bvFTD = behavioral variant of frontotemporal dementia. CI = confidence interval. CST = cognitive stimulation therapy. FER = facial emotion recognition. RE = random effects.
FIGURE 3
FIGURE 3
Forest plot of the cognitive approach to intervention with FER as the outcome variable. CI = confidence interval. FER = facial emotion recognition. RE = random effects.
FIGURE 4
FIGURE 4
Forest plot of the neurostimulation approach to intervention with FER as the outcome variable. CI = confidence interval. FER = facial emotion recognition. RE = random effects.
See this image and copyright information in PMC

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References

    1. Abbruzzese L, Magnani N, Robertson IH, et al. . 2019. Age and gender differences in emotion recognition. Front Psychol. 10:2371. doi:10.3389/fpsyg.2019.02371 - DOI - PMC - PubMed
    1. Accolla EA, Herrojo Ruiz M, Horn A, et al. . 2016. Brain networks modulated by subthalamic nucleus deep brain stimulation. Brain. 139:2503–2515. doi:10.1093/brain/aww182 - DOI - PubMed
    1. Aiello M, Eleopra R, Lettieri C, et al. . 2014. Emotion recognition in Parkinson’s disease after subthalamic deep brain stimulation: differential effects of microlesion and STN stimulation. Cortex. 51:35–45. doi:10.1016/j.cortex.2013.11.003 - DOI - PubMed
    1. Albuquerque L, Coelho M, Martins M, et al. . 2014. STN-DBS does not change emotion recognition in advanced Parkinson’s disease. Parkinsonism Relat Disord. 20:166–169. doi:10.1016/j.parkreldis.2013.10.010 - DOI - PubMed
    1. Allen AP, Buckley MM, Cryan JF, et al. . 2019. Informal caregiving for dementia patients: the contribution of patient characteristics and behaviours to caregiver burden. Age Ageing. 49:52–56. doi:10.1093/ageing/afz128 - DOI - PubMed