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Comment
. 2023 Sep;39(9):642-643.
doi: 10.1016/j.tig.2023.06.005. Epub 2023 Jul 4.

An miRNA with a major impact on stress

Sarah Cooper Simmons  1 , A J Robison  2
Affiliations
Comment

An miRNA with a major impact on stress

Sarah Cooper Simmons et al. Trends Genet. 2023 Sep.

Abstract

miRNAs regulate mRNAs, including those important for synapse function in the brain. Mucha and colleagues recently identified a novel miRNA-mRNA interaction in the basolateral amygdala that acts as a homeostatic counter to stress-induced anxiety and synaptic changes, suggesting miRNAs as potential avenues for therapeutic intervention in anxiety disorders.

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Conflict of interest statement

Declaration of interests The authors declare that they have no conflicts of interest with the contents of this article.

Figures

Figure 1:
Figure 1:. Model of miR-483-5p in response to stress.
Stress induces anxiety-like behavior and the growth of immature dendritic spines in the amygdala. Stress also induces the expression of miR-483-5p in the amygdala, which drives down expression of Pgap2 and homeostatically prevents immature spine formation and anxiety. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

References

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    1. Mucha M, et al., miR-483-5p offsets functional and behavioural effects of stress in male mice through synapse-targeted repression of Pgap2 in the basolateral amygdala. Nat Commun, 2023. 14. - PMC - PubMed

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