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. 2023 Jun;14(3):173-179.
doi: 10.24171/j.phrp.2022.0285. Epub 2023 Jun 22.

Results of contact tracing for SARS-CoV-2 Omicron sub-lineages (BA.4, BA.5, BA.2.75) and the household secondary attack risk

Mi Yu  1 , Sang-Eun Lee  1 , Hye Young Lee  1 , Hye-Jin Kim  1 , Yeong-Jun Song  1 , Jian Jeong  1 , Ae Kyung Park  2 , Il-Hwan Kim  2 , Eun-Jin Kim  2 , Young-Joon Park  1
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Results of contact tracing for SARS-CoV-2 Omicron sub-lineages (BA.4, BA.5, BA.2.75) and the household secondary attack risk

Mi Yu et al. Osong Public Health Res Perspect. 2023 Jun.

Abstract

Background: This study aimed to assess the contact tracing outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sub-lineages BA.4, BA.5, and BA.2.75 within Republic of Korea, and to generate foundational data for responding to future novel variants.

Methods: We conducted investigations and contact tracing for 79 confirmed BA.4 cases, 396 confirmed BA.5 cases, and 152 confirmed BA.2.75 cases. These cases were identified through random sampling of both domestically confirmed and imported cases, with the goal of evaluating the pattern of occurrence and transmissibility.

Results: We detected 79 instances of Omicron sub-lineage BA.4 across a span of 46 days, 396 instances of Omicron sub-lineage BA.5 in 46 days, and 152 instances of Omicron sub-lineage BA.2.75 over 62 days. One patient with severe illness was confirmed among the BA.5 cases; however, there were no reports of severe illness in the confirmed BA.4 and BA.2.75 cases. The secondary attack risk among household contacts were 19.6% for BA.4, 27.8% for BA.5, and 24.3% for BA.2.75. No statistically significant difference was found between the Omicron sub-lineages.

Conclusion: BA.2.75 did not demonstrate a higher tendency for transmissibility, disease severity, or secondary attack risk within households when compared to BA.4 and BA.5. We will continue to monitor major SARS-CoV-2 variants, and we plan to enhance the disease control and response systems.

Keywords: COVID-19; Epidemiology; Risk; Secondary attack rate; Variants.

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Conflict of interest statement

Conflicts of Interest

The authors have no conflicts of interest to declare.

Figures

Figure 1.
Figure 1.
Incidence of cases during the monitoring period for severe acute respiratory syndrome coronavirus 2 Omicron variant sub-lineages (BA.4, BA.5, and BA.2.75). MA, moving average.
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