Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun 21:14:1059303.
doi: 10.3389/fendo.2023.1059303. eCollection 2023.

Association between diabetes status and breast cancer in US adults: findings from the US National Health and Nutrition Examination Survey

Xingyu Sun  1   2 , Qiangsong Zhang  3 , Kaisaierjiang Kadier  4 , Pengcheng Hu  5 , Xiaozhu Liu  6 , Jialing Liu  7 , Yulu Yan  8 , Chenyu Sun  9   10 , Vicky Yau  11 , Scott Lowe  12 , Muzi Meng  13   14 , Ziru Liu  1 , Meirong Zhou  1
Affiliations

Association between diabetes status and breast cancer in US adults: findings from the US National Health and Nutrition Examination Survey

Xingyu Sun et al. Front Endocrinol (Lausanne). .

Abstract

Objectives: The aim of this study was to investigate the association between diabetes status and the risk of breast cancer among adult Americans, exploring the impact of BMI, age, and race on this relationship.

Methods: A cross-sectional analysis of 8,249 individuals from the National Health and Nutrition Examination Survey (NHANES) was conducted. Diabetes was categorized as type 2 diabetes and prediabetes, with both conditions diagnosed according to the ADA 2014 guidelines. The association between diabetes status and breast cancer risk was explored using multiple logistic regression analysis.

Results: Patients with diabetes had higher odds of breast cancer (OR: 1.51; 95% CI 1.00 to 2.28), Using the two-piecewise linear regression model, it was observed that there is a threshold effect in the risk of breast cancer occurrence at the age of 52 years. Specifically, the risk of breast cancer is relatively low before the age of 52 but increases significantly after this age.

Conclusions: This study identified a significant association between diabetes status and breast cancer risk among adult Americans. We also found a threshold effect in breast cancer occurrence at the age of 52. Age was significantly associated with breast cancer risk in both Non-Hispanic White and Non-Hispanic Black individuals. These findings underscore the importance of diabetes management, maintaining a healthy BMI, and age-related risk considerations in reducing breast cancer risk.

Keywords: NHANES; breast cancer; diabetes status; obesity; prediabetes; type 2 diabetes.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Research flowchart.
Figure 2
Figure 2
The association between BMI and breast cancer risk.
Figure 3
Figure 3
The association between BMI and breast cancer risk among different populations.
Figure 4
Figure 4
The association between age and breast cancer risk.
Figure 5
Figure 5
The association between age and breast cancer risk among different populations.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. World Cancer Research Fund . Breast cancer statistics . World Cancer Research Research Fund International. Available at: https://www.wcrf.org/dietandcancer/cancer-trends/breast-cancer-statistics (Accessed August 17, 2020).
    1. Centers for Disease Control and Prevention . Breast cancer statistics . Centers for Disease Control and Prevention. Available at: https://www.cdc.gov/cancer/breast/statistics/index.htm (Accessed August 17, 2020).
    1. The American Cancer Society medical and editorial content team . About breast cancer (2020). AmericanCancerSociety,Inc. Available at: https://www.cancer.org/cancer/breast-cancer/about/how-common-is-breast-c... (Accessed August 17, 2020).
    1. Nagy TR, Maistro S, Encinas G, Katayama MLH, Pereira GFL, Gaburo-Júnior N, et al. . Germline and somatic mutations in postmenopausal breast cancer patients. Clinics (Sao Paulo). (2021) 76:e2837. doi: 10.6061/clinics/2021/e2837 - DOI - PMC - PubMed
    1. Paths to prevention the California breast cancer primary prevention plan . Available at: https://escholarship.org/uc/item/1v2745z0 (Accessed 1 December 2020).