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. 2022 Nov 25;83(1):49-78.
doi: 10.1055/a-1895-9940. eCollection 2023 Jan.

Recurrent Miscarriage: Diagnostic and Therapeutic Procedures. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/050, May 2022)

Bettina Toth  1 , Michael Bohlmann  2 , Katharina Hancke  3 , Ruben Kuon  4 , Frank Nawroth  5 , Sören von Otte  6 , Nina Rogenhofer  7 , Sabine Rudnik-Schöneborn  8 , Ekkehard Schleußner  9 , Clemens Tempfer  10 , Kilian Vomstein  1 , Tewes Wischmann  11 , Michael von Wolff  12 , Wolfgang Würfel  13 , Johannes Zschocke  8
Affiliations

Recurrent Miscarriage: Diagnostic and Therapeutic Procedures. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/050, May 2022)

Bettina Toth et al. Geburtshilfe Frauenheilkd. .

Abstract

Purpose The aim of this guideline is to standardize the diagnosis and therapy of recurrent miscarriage (RM) using evidence from the recent literature. This is done by using consistent definitions, objective evaluations and standardized treatment protocols. Methods When this guideline was compiled, special consideration was given to previous recommendations in prior versions of this guideline and the recommendations of the European Society of Human Reproduction and Embryology, the Royal College of Obstetricians and Gynecologists, the American College of Obstetricians and Gynecologists and the American Society for Reproductive Medicine, and a detailed individual search of the literature about the different topics was carried out. Recommendations Recommendations about the diagnostic and therapeutic procedures offered to couples with RM were developed based on the international literature. Special attention was paid to known risk factors such as chromosomal, anatomical, endocrinological, physiological coagulation, psychological, infectious and immune disorders. Recommendations were also developed for those cases where investigations are unable to find any abnormality (idiopathic RM).

Keywords: diagnosis; guideline; incidence; recurrent miscarriage; recurrent pregnancy loss; therapy.

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Conflict of interest statement

Conflict of Interest/Interessenkonflikt The authorsʼ conflicts of interest are listed in the long version of the guideline./Die Interessenkonflikte der Autoren sind in der Langfassung der Leitlinie aufgelistet.

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