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. 2023 Jun 19;9(6):e17383.
doi: 10.1016/j.heliyon.2023.e17383. eCollection 2023 Jun.

Reduction of obesity and hepatic adiposity in high-fat diet-induced rats by besunyen slimming tea

Chingwen Yu  1 , Xiaoning Wan  1 , Dan Li  1 , Xiaomei Guo  1
Affiliations

Reduction of obesity and hepatic adiposity in high-fat diet-induced rats by besunyen slimming tea

Chingwen Yu et al. Heliyon. .

Abstract

Objective: Obesity is a significant risk factor for metabolic syndrome, type 2 diabetes mellitus, hypertension, nonalcoholic fatty liver disease, and cardiovascular disorders. As a well-known Chinese tea product, Besunyen Slimming Tea (BST) is believed to effectively reduce body weight (BW) and lipid profile. In this study, we aimed to elucidate the mechanisms and effects of BST on treating obesity and hepatic steatosis using a rat model fed with a high-fat diet (HFD).

Methods: Sprague-Dawley rats were subjected to random separation into three categories: Animals were fed (1) a normal diet food (ND); (2) HFD, and (3) HFD + BST (n = 12/category). After successfully establishing the obesity model at week 8, the HFD + BST received BST (0.6 g/0.6 kg) orally, and the ND and HFD received the same amount (2 ml) of distilled water orally.

Results: HFD + BST reduced waist circumference (7.84%, P = 0.015), food intake (14.66%, P = 0.011), final BW (12.73%, P = 0.010), BW gain (964.16%, P < 0.001), and body mass index (8.97%, P = 0.044) compared with the HFD. BST supplementation also decreased hyperlipidemia, inflammation, and insulin resistance in rats with HFD. Furthermore, BST suppressed hepatic lipidosis by decreasing de novo lipogenesis and increasing fatty acid oxidation.

Conclusions: The results of this study offer evidence supporting the potential health benefits of BST in the management of metabolic disorders and obesity.

Keywords: Fatty acid oxidation; Flavonoids; High fat diet; Lipogenesis; Liver; Obesity; Tea polyphenols.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
(A) Main compounds in BST are indicated by < mzCloud Best Match score>, retention time/min, [molecular weight], (chemical formula), and name. (B) Red and black denote the total ion current diagram in negative and positive ion modes, respectively.
Fig. 2
Fig. 2
(A) Experimental scheme and (B) BW changes of rats in each category. Values were obtained by One-Way ANOVA multi-group comparison and denoted as means (n = 12); x, P ≤ 0.001, ND vs. HFD; y, P ≤ 0.019, HFD + BST vs. HFD.
Fig. 3
Fig. 3
BST inhibited HFD-induced hepatic lipidosis. Liver HE staining in the (A) ND, (B) HFD, and (C) HFD + BST (200 ×, vacuoles indicated by arrows).
Fig. 4
Fig. 4
BST promoted fatty acid oxidation and inhibited de novo lipogenesis in the liver. In each category, (A) SREBP1c, (B) ACC, (C) FAS, (D) CPT1α, (E) PPARα, and (F) AMPK gene expression. Values were denoted as mean ± SD (n = 12) (with GAPDH as control), multi-group comparison by One-way ANOVA. P ≤ 0.05, P ≤ 0.01, and P ≤ 0.001 were denoted as #, ##, ### vs. ND, and *, **, *** vs. HFD, respectively.
See this image and copyright information in PMC

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