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Comment
. 2023 Jul 7;13(7):1516-1517.
doi: 10.1158/2159-8290.CD-23-0495.

Modeling the Landscape of Histone-Mutant Pediatric High-Grade Gliomas: A Study in Partner Alterations

Evan Lubanszky  1   2 , Cynthia Hawkins  1   2   3
Affiliations
Comment

Modeling the Landscape of Histone-Mutant Pediatric High-Grade Gliomas: A Study in Partner Alterations

Evan Lubanszky et al. Cancer Discov. .

Abstract

Pediatric high-grade gliomas represent a group of deadly, heterogeneous tumors, often driven by histone mutations and the accumulation of clonal mutations, correlating with different tumor types, locations, and age of onset. In this study, McNicholas and colleagues present 16 in vivo models of histone-driven gliomas to investigate subtype-specific tumor biology and treatment options. See related article by McNicholas et al., p. 1592 (7).

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