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. 2023 Jul-Sep;22(3):246-251.
doi: 10.4103/aam.aam_157_21.

Spectrum of high-resolution computed tomography pattern in lungs in patients with connective tissue disorders

Maheswar Chaudhury  1 , E Hari Kishore  1 , Likhitha Lingam  1 , Adya Kinkar Panda  1
Affiliations

Spectrum of high-resolution computed tomography pattern in lungs in patients with connective tissue disorders

Maheswar Chaudhury et al. Ann Afr Med. 2023 Jul-Sep.

Abstract
in English, French

Background: Connective tissue disease associated with interstitial lung disease, or CT-ILD, is a lung condition that affects a large number of patients with a connective tissue disease.

Objective: Our aim in this study is to correlation between images of high-resolution computed tomography (HRCT) of different connective tissue diseases associated interstitial lung diseases (CTD-ILDs).

Methods: We shall be aiming to investigate the feasibility of HRCT imaging and thereby avoid lung biopsy in such patients.

Results: Rheumatoid arthritis predominantly presented with usual interstitial pneumonia (UIP) (47.8%), followed by nonspecific interstitial pneumonia (NSIP) (30.4%). Mixed connective tissue disorder predominantly presented with NSIP and UIP (42.8%), followed by organizing pneumonia (OP) (14.2%). Systemic lupus erythematosus predominantly presented with UIP (38.8%), followed by NSIP (27.7%). Sjogren's syndrome predominantly presented with lymphocytic interstitial pneumonia (40%), followed by UIP (26.6%). Scleroderma predominantly presented with UIP (45.4%), followed by NSIP (36.4%). Sarcoidosis predominantly presented with UIP (75%), followed by NSIP (25%). Dermatomyositis predominantly presented with NSIP (50%), followed by UIP and OP each (25%).

Conclusion: Both clinicians and radiologists should be aware of the expected evolution of HRCT changes in a variety of CT-ILDs.

Résumé Contexte: La maladie du tissu conjonctif associée à la maladie pulmonaire interstitielle, ou CT ILD, est une affection pulmonaire qui affecte un grand nombre de patients atteints d'une maladie du tissu conjonctif. Objectif: Notre objectif dans cette étude est de mettre en corrélation des images de tomodensitométrie à haute résolution (HRCT) de différentes maladies du tissu conjonctif associées à des maladies pulmonaires interstitielles (CTD ILDs). Méthodes: Notre objectif sera d'étudier la faisabilité de l'imagerie HRCT et d'éviter ainsi la biopsie pulmonaire chez ces patients. Résultats: La polyarthrite rhumatoïde se présentait principalement avec une pneumonie interstitielle habituelle (PUI) (47,8 %), suivie d'une pneumonie interstitielle non spécifique (NSIP) (30,4 %). Trouble mixte du tissu conjonctif présenté principalement avec NSIP et UIP (42,8 %), suivi d'une pneumonie organisée (OP) (14,2 %). Le lupus érythémateux disséminé présentait principalement une UIP (38,8 %), suivie d'une NSIP (27,7 %). Le syndrome de Sjogren présentait principalement une pneumonie interstitielle lymphocytaire (40 %), suivie d'une PUI (26,6 %). La sclérodermie se présentait principalement avec l'UIP (45,4 %), suivi du NSIP (36,4 %). La sarcoïdose se présentait principalement avec l'UIP (75 %), suivi du NSIP (25 %). La dermatomyosite se présentait principalement avec NSIP (50 %), suivi par UIP et OP chacun (25 %). Conclusion: Les cliniciens et les radiologues doivent être conscients de l'évolution attendue des changements HRCT dans une variété d'ILD CT. Mots-clés: Tissu conjonctif, CT ILDs, tomodensitométrie haute résolution, poumon interstitiel.

Keywords: CT-ILDs; Connective tissue; high-resolution computed tomography; interstitial lung.

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
Demographics of connective tissue disorders. MCTD = Mixed connective tissue disorder, SLE = Systemic lupus erythematosus
Figure 2
Figure 2
Spectrum of HRCT ILD patterns in respective connective tissue disorders. HRCT = High-resolution computed tomography, ILD = Interstitial lung disease, NSIP = Nonspecific interstitial pneumonia, UIP = Usual interstitial pneumonia, OP = Organizing pneumonia, LIP = Lymphocytic interstitial pneumonia, DAD = Diffuse alveolar damage, MCTD = Mixed connective tissue disorder, SLE = Systemic lupus erythematosus
Figure 3
Figure 3
Incidence of HRCT imaging findings in different connective disease
See this image and copyright information in PMC

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