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. 1986 Aug;54(2):239-43.
doi: 10.1038/bjc.1986.168.

The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro

H Eichholtz-Wirth, B Hietel
Free PMC article

The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro

H Eichholtz-Wirth et al. Br J Cancer. 1986 Aug.
Free PMC article

Abstract

Clonogenic survival of HeLa, Chinese hamster and HaK cells after treatment with a range of cisplatin concentrations and exposure times was determined and cellular platinum concentrations were measured by PIXE. It was demonstrated that cisplatin cytotoxicity of the three cell lines varied considerably as a function of drug exposure dose. These differences are related to differential cellular drug uptake.

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