Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2023 Sep;9(5):2192-2200.
doi: 10.1002/vms3.1196. Epub 2023 Jul 7.

Global prevalence of Neospora caninum in rodents: A systematic review and meta-analysis

Yazdan Hamzavi  1 , Yahya Salimi  2 , Mobin Ahmadi  3 , Parvaneh Adimi  4 , Sahab Falahi  5 , Arezoo Bozorgomid  1
Affiliations
Meta-Analysis

Global prevalence of Neospora caninum in rodents: A systematic review and meta-analysis

Yazdan Hamzavi et al. Vet Med Sci. 2023 Sep.

Abstract

Background: Neosporosis has been considered a cause of abortion in dairy and beef cattle worldwide. Rodents are reservoir hosts for several infectious diseases. It is necessary to determine the prevalence of Neospora caninum in rodents to improve the current understanding of the transmission dynamics of Neospora as well as its life cycle and risk of transmission to livestock. Therefore, the objective of the present study was to estimate the pooled global prevalence of N. caninum in different rodent species.

Methods: Published studies on the prevalence of N. caninum in different rodent species were searched in the MEDLINE/PubMed, ScienceDirect, Web of Science, Scopus and Google Scholar and the reference lists of the retrieved articles until July 30, 2022. The eligible studies were selected using inclusion and exclusion criteria. The extracted data were verified and analysed using the random-effect meta-analysis.

Result: For this meta-analysis, a total of 4372 rodents from 26 eligible studies were included. The global prevalence of N. caninum in rodents was estimated at 5% (95% CI 2%-9%), with the highest prevalence in Asia (12%; 95% CI 6%-24%) and lowest prevalence in America (3%; 95% CI 1%-14%) and Europe (3%; 95% CI 1%-6%). N. caninum was more prevalent in females (4%; 95% CI 2%-9%) than in males (3%; 95% CI 1%-11%). The most common diagnostic test was polymerase chain reaction (PCR) (21 studies). The pooled prevalence of N. caninum in rodents based on the diagnostic method was as follows: immunohistochemistry: 11% (95% CI 6%-20%), NAT: 5% (95% CI 4%-7%), IFAT: 5% (95% CI 2%-13%) and PCR: 3% (95% CI 1%-9%).

Conclusion: The results of this study showed a relatively low but widespread prevalence of N. caninum infection in rodents.

Keywords: Neospora; meta-analysis; neosporosis; prevalence; rodent; systematic review.

PubMed Disclaimer

Conflict of interest statement

All the authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) flow diagram describing included/excluded studies.
FIGURE 2
FIGURE 2
Forest plot of the global prevalence of Neospora caninum in rodents.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. de Abreu, J. A. P. , da Silva Krawczak, F. , Nunes, F. P. , Labruna, M. B. , & de Jesus Pena, H. F. (2016). Anti‐Toxoplasma gondii and anti‐Neospora caninum antibodies in capybaras (Hydrochoerus hydrochaeris) from Itu Municipality, São Paulo. Revista Brasileira de Parasitologia Veterinária, 25(1), 116–118. - PubMed
    1. Akya, A. , Bozorgomid, A. , Ghadiri, K. , Ahmadi, M. , Elahi, A. , Mozafari, H. , Almasi, A. , Namadi, P. , & Chegenelorestani, R. (2020). Usefulness of blood parameters for preliminary diagnosis of brucellosis. Journal of Blood Medicine, 11, 107–113. - PMC - PubMed
    1. Almería, S. (2013). Neospora caninum and wildlife. International Scholarly Research Notices, 2013, 947347.
    1. Ansari‐Lari, M. (2021). Neospora caninum in aborted bovine fetuses in Iran: A systematic review and meta‐analysis. Annals of Parasitology, 67(3), 357–366. - PubMed
    1. Anvari, D. , Saberi, R. , Sharif, M. , Sarvi, S. , Hosseini, S. A. , Moosazadeh, M. , Hosseininejad, Z. , Chegeni, T. N. , & Daryani, A. (2020). Seroprevalence of Neospora caninum infection in dog population worldwide: A systematic review and meta‐analysis. Acta Parasitologica, 65(2), 273–290. - PubMed

LinkOut - more resources