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. 2023 Sep;43(9):1695-1704.
doi: 10.1007/s00296-023-05379-2. Epub 2023 Jul 7.

Beyond expectations: disease duration and psychological burden in psoriatic arthritis

Gamze Kılıç  1 , Erkan Kılıç  2 , İbrahim Tekeoğlu  3 , Betül Sargın  4 , Gizem Cengiz  5 , Nihan Cüzdan Balta  6 , Hakan Alkan  7 , Sevtap Acer Kasman  8 , Nilay Şahin  9 , Kevser Orhan  10 , İlknur Albayrak Gezer  11 , Dilek Keskin  12 , Cevriye Mülkoğlu  13 , Hatice Reşorlu  14 , Şebnem Ataman  15 , Ajda Bal  16 , Mehmet Tuncay Duruöz  8 , Okan Küçükakkaş  17 , Nesrin Şen  18 , Murat Toprak  19 , Ozan Volkan Yurdakul  17 , Meltem Alkan Melikoğlu  20 , Fikriye Figen Ayhan  21 , Merve Baykul  3 , Hatice Bodur  22 , Mustafa Çalış  5 , Erhan Çapkın  23 , Gül Devrimsel  24 , Sami Hizmetli  25 , Ayhan Kamanlı  3 , Yaşar Keskin  17 , Hilal Ecesoy  26 , Öznur Kutluk  27 , Ömer Faruk Şendur  28 , Sena Tolu  29 , Tiraje Tuncer  27 , Kemal Nas  3
Affiliations

Beyond expectations: disease duration and psychological burden in psoriatic arthritis

Gamze Kılıç et al. Rheumatol Int. 2023 Sep.

Abstract

This study aims to investigate the relationship between disease duration and psychological burden in PsA and to identify the risk factors associated with psychological distress. Patients with PsA who met CASPAR classification criteria enrolled by Turkish League Against Rheumatism (TLAR)-Network. Patients were categorized into three groups based on disease duration: early stage (< 5 years), middle stage (≥ 5, < 10 years), and late stage (≥ 10 years). All patients underwent clinical and laboratory assessment using standardized protocol and case report forms. The associations between psychological variables and clinical parameters were assessed by a multivariate analysis. Of the 1113 patients with PsA (63.9% female), 564 (%50.7) had high risk for depression and 263 (%23.6) for anxiety. The risk of psychological burden was similar across all PsA groups, and patients with a higher risk of depression and anxiety also experienced greater disease activity, poorer quality of life, and physical disability. Multivariate logistic regression revealed that female gender (OR = 1.52), PsAQoL (OR = 1.13), HAQ (OR = 1.99), FiRST score (OR = 1.14), unemployment/retired (OR = 1.48) and PASI head score (OR = 1.41) were factors that influenced the risk of depression, whereas the current or past enthesitis (OR = 1.45), PsAQoL (OR = 1.19), and FiRST score (OR = 1.26) were factors that influenced the risk of anxiety. PsA patients can experience a comparable level of psychological burden throughout the course of their disease. Several socio-demographic and disease-related factors may contribute to mental disorders in PsA. In the present era of personalized treatment for PsA, evaluating psychiatric distress can guide tailored interventions that improve overall well-being and reduce disease burden.

Keywords: Anxiety; Arthritis; Depression; Psoriatic; Quality of life; Rheumatic diseases.

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