Neurobiological Mechanisms of Cognitive Decline Correlated with Brain Aging
- PMID: 37418211
- DOI: 10.1007/978-981-99-1627-6_10
Neurobiological Mechanisms of Cognitive Decline Correlated with Brain Aging
Abstract
Cognitive decline has emerged as one of the greatest health threats of old age. Meanwhile, aging is the primary risk factor for Alzheimer's disease (AD) and other prevalent neurodegenerative disorders. Developing therapeutic interventions for such conditions demands a greater understanding of the processes underlying normal and pathological brain aging. Despite playing an important role in the pathogenesis and incidence of disease, brain aging has not been well understood at a molecular level. Recent advances in the biology of aging in model organisms, together with molecular- and systems-level studies of the brain, are beginning to shed light on these mechanisms and their potential roles in cognitive decline. This chapter seeks to integrate the knowledge about the neurological mechanisms of age-related cognitive changes that underlie aging.
Keywords: AD; Demyelination; Neurovascular unit injury; Synaptic plasticity; White matter.
© 2023. Springer Nature Singapore Pte Ltd.
Similar articles
-
Neural mechanisms of ageing and cognitive decline.Nature. 2010 Mar 25;464(7288):529-35. doi: 10.1038/nature08983. Nature. 2010. PMID: 20336135 Free PMC article. Review.
-
Age-related neuropathology, cognitive decline, and Alzheimer's disease.Ageing Res Rev. 2006 Feb;5(1):1-13. doi: 10.1016/j.arr.2005.06.002. Epub 2005 Aug 9. Ageing Res Rev. 2006. PMID: 16084778 Review.
-
The aging brain.Annu Rev Pathol. 2008;3:41-66. doi: 10.1146/annurev.pathmechdis.2.010506.092044. Annu Rev Pathol. 2008. PMID: 18039130 Review.
-
An Overview.Adv Exp Med Biol. 2023;1419:1-5. doi: 10.1007/978-981-99-1627-6_1. Adv Exp Med Biol. 2023. PMID: 37418202
-
Differential spatial distribution of white matter lesions in Parkinson's and Alzheimer's diseases and cognitive sequelae.J Neural Transm (Vienna). 2022 Aug;129(8):1023-1030. doi: 10.1007/s00702-022-02519-z. Epub 2022 Jul 11. J Neural Transm (Vienna). 2022. PMID: 35819634
References
-
- Burke SN, Barnes CA (2006) Neural plasticity in the ageing brain. Nature Rev Neurosci 7(1):30–40 - DOI
-
- Crook T, Bartus RT, Ferris SH, Whitehouse P, Cohen GD, Gershon S (1986) Age associated memory impairment: proposed diagnostic criteria and measures of clinical change — report of a national institute of mental health work group. Dev Neuropsychol 2(4):261–276 - DOI
MeSH terms
LinkOut - more resources
Full Text Sources
Medical