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Comment
. 2023 Jul 6;83(13):2164-2166.
doi: 10.1016/j.molcel.2023.05.037.

CircR-looping the leukemic translocations: The cause of MLL translocations explained

Mo Chen  1
Affiliations
Free article
Comment

CircR-looping the leukemic translocations: The cause of MLL translocations explained

Mo Chen. Mol Cell. .
Free article

Abstract

Conn et al.1 identify circular RNAs (circRNAs) derived from mixed lineage leukemia (MLL) breakpoint cluster regions, demonstrating a causal role of circRNAs in MLL translocations. CircRNAs:DNA hybrids (circR-loops) trigger RNA polymerase pausing, driving oncogenic gene fusions via endogenous RNA-directed DNA damage.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

Comment on

  • Circular RNAs drive oncogenic chromosomal translocations within the MLL recombinome in leukemia.
    Conn VM, Gabryelska M, Toubia J, Kirk K, Gantley L, Powell JA, Cildir G, Marri S, Liu R, Stringer BW, Townley S, Webb ST, Lin H, Samaraweera SE, Bailey S, Moore AS, Maybury M, Liu D, Colella AD, Chataway T, Wallington-Gates CT, Walters L, Sibbons J, Selth LA, Tergaonkar V, D'Andrea RJ, Pitson SM, Goodall GJ, Conn SJ. Conn VM, et al. Cancer Cell. 2023 Jul 10;41(7):1309-1326.e10. doi: 10.1016/j.ccell.2023.05.002. Epub 2023 Jun 8. Cancer Cell. 2023. PMID: 37295428

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