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Comment
. 2023 Jul 6;30(7):909-910.
doi: 10.1016/j.stem.2023.05.013.

Context matters: hPSC-derived microglia thrive in a humanized brain environment in vivo

Jonas Cerneckis  1 , Yanhong Shi  2
Affiliations
Comment

Context matters: hPSC-derived microglia thrive in a humanized brain environment in vivo

Jonas Cerneckis et al. Cell Stem Cell. .

Abstract

It remains challenging to create a physiologically relevant human-brain-like environment that would support maturation of human pluripotent stem cell (hPSC)-derived microglia (hMGs). Schafer et al.1 (Cell, 2023) now develop an in vivo neuroimmune organoid model with mature homeostatic hMGs for the study of brain development and disease.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • An in vivo neuroimmune organoid model to study human microglia phenotypes.
    Schafer ST, Mansour AA, Schlachetzki JCM, Pena M, Ghassemzadeh S, Mitchell L, Mar A, Quang D, Stumpf S, Ortiz IS, Lana AJ, Baek C, Zaghal R, Glass CK, Nimmerjahn A, Gage FH. Schafer ST, et al. Cell. 2023 May 11;186(10):2111-2126.e20. doi: 10.1016/j.cell.2023.04.022. Cell. 2023. PMID: 37172564 Free PMC article.

References

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