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. 2023 Aug 7;33(15):3111-3124.e5.
doi: 10.1016/j.cub.2023.06.057. Epub 2023 Jul 6.

Plant myo-inositol transport influences bacterial colonization phenotypes

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Free article

Plant myo-inositol transport influences bacterial colonization phenotypes

Bridget S O'Banion et al. Curr Biol. .
Free article

Abstract

Plant microbiomes are assembled and modified through a complex milieu of biotic and abiotic factors. Despite dynamic and fluctuating contributing variables, specific host metabolites are consistently identified as important mediators of microbial interactions. We combine information from a large-scale metatranscriptomic dataset from natural poplar trees and experimental genetic manipulation assays in seedlings of the model plant Arabidopsis thaliana to converge on a conserved role for transport of the plant metabolite myo-inositol in mediating host-microbe interactions. While microbial catabolism of this compound has been linked to increased host colonization, we identify bacterial phenotypes that occur in both catabolism-dependent and -independent manners, suggesting that myo-inositol may additionally serve as a eukaryotic-derived signaling molecule to modulate microbial activities. Our data suggest host control of this compound and resulting microbial behavior are important mechanisms at play surrounding the host metabolite myo-inositol.

Keywords: Arabidopsis; GWAS; host-microbe interactions; myo-inositol; poplar; root colonization.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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