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Meta-Analysis
. 2023 Jul 7;23(1):142.
doi: 10.1186/s12902-023-01390-7.

Effect of Orlistat on anthropometrics and metabolic indices in children and adolescents: a systematic review and meta-analysis

Zeinab Nikniaz  1 , Leila Nikniaz  2 , Mahdieh Abbasalizad Farhangi  3 , Hossein Mehralizadeh  4 , Shabnam Salekzamani  5   6
Affiliations
Meta-Analysis

Effect of Orlistat on anthropometrics and metabolic indices in children and adolescents: a systematic review and meta-analysis

Zeinab Nikniaz et al. BMC Endocr Disord. .

Abstract

Background: Childhood obesity is one of the main concerns of public health. Considering its long-term adverse health effect, various studies investigated the effect of drug therapy on anthropometric parameters and provided mixed results. In this systematic review and meta-analysis, we aimed to determine the effect of Orlistat on anthropometrics and biochemical parameters in children and adolescents.

Materials and methods: The databases of PubMed, Scopus, and Web of Science were searched until September 2022. Experimental and semi-experimental studies were included if they evaluated the effect of Orlistat on obesity-related parameters in children and reported the before and after anthropometric values. A revised Cochrane risk-of-bias (Rob2) was used to evaluate the methodological quality. STATA software version 16.0 was used for the meta-analysis of the random-effect model.

Results: Of 810 articles retrieved in the initial search, four experimental and two semi-experimental studies were selected for systematic review. The result of the meta-analysis of experimental studies indicated the significant effect of Orlistat on waist circumference (SMD: -0.27, 95% CI: -0.47, -0.07) and serum insulin level (SMD: -0.89, 95% CI: -1.52, 0.26). However, there were no significant effects of orlistat on body weight, body mass index, lipid profile, and serum glucose level.

Conclusion: The present meta-analysis showed the significant effect of Orlistat on the reduction of waist circumference and insulin level in overweight and obese adolescents. However, due to the paucity of studies included in the meta-analysis, more prospective studies with longer duration and more sample sizes will be needed in this age group.

Keywords: Adolescents; Anthropometry; Children; Metabolic Indices; Orlistat.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram
Fig. 2
Fig. 2
The result of risk of bias. D1: Randomization process; D2: Deviations from the intended interventions; D3: Missing outcome data; D4: Measurement of the outcome; D5: Selection of the reported result
Fig. 3
Fig. 3
The effect Orlistat on A: weight, B: body mass index;C: waist circumference
Fig. 4
Fig. 4
The effect Orlistat on A: Total cholesterol, B: LDL-C; C: HDL-C; D: triglyceride
Fig. 5
Fig. 5
The effect Orlistat on A: serum Glucose, B: insulin
See this image and copyright information in PMC

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