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. 2023 Jan-Dec:30:10732748231180745.
doi: 10.1177/10732748231180745.

Diagnostic Value of Inflammation-Related Indicators in Distinguishing Early Colon Cancer and Adenomatous Polyps

Zhewen Feng  1 , Huajun Lin  1 , Xiaobao Yang  1 , Shun Cao  1 , Xiaozhe Gu  1 , Zhongtao Zhang  1 , Wei Deng  1
Affiliations

Diagnostic Value of Inflammation-Related Indicators in Distinguishing Early Colon Cancer and Adenomatous Polyps

Zhewen Feng et al. Cancer Control. 2023 Jan-Dec.

Abstract

Background: There are few clinical symptoms in early colorectal cancer, so it is necessary to find a simple and economical tumor detection index for auxiliary diagnosis. This study aims to explore the diagnostic value of preoperative inflammation-related indicators, such as neutrophil, lymphocyte, platelet count, platelet to lymphocyte ratio (PLA), neutrophil to lymphocyte ratio (NLR), and systemic immune-inflammation index (SII), for early colorectal cancer, and determine whether inflammation-related indicators can provide more accurate diagnostic judgment for patients.

Methods: This study was a retrospective study. Patients who were first diagnosed with colorectal cancer or colorectal adenomatous polyp at Beijing Friendship Hospital from October 2016 to October 2017 were retrospectively collected. According to inclusion and exclusion criteria, a total of 342 patients were included, including 216 patients with colorectal cancer and 126 patients with colorectal adenomatous polyp. Fasting venous blood and other clinical features were collected to compare the differences between colorectal cancer and colorectal adenoma.

Results: There were statistically significant differences in age, carcinoembryonic antigen, albumin, hemoglobin, mean platelet volume, lymphocyte, monocyte, NLR, PLA, SII, and mean platelet volume to platelet count ratio between colorectal cancer group and colorectal adenoma group (P < .05), and a Nomogram model was established. Using inflammatory markers to differentiate colorectal and colorectal polyps produced greater AUC than using tumor markers alone (.846 vs .695).

Conclusion: Inflammation-related indicators, such as lymphocyte, monocyte, and mean platelet volume, may serve as potential indicators to assist in the diagnosis of early colorectal cancer.

Keywords: adenomatous polyps; colorectal cancer; inflammation-related indicators; lymphocyte; mean platelet volume; monocyte; nomogram.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Comparison of inflammation-related indexes between colorectal cancer group and adenomatous polyp group. (A) Comparison of neutrophil count, lymphocyte count, monocyte count, MPV, MPV/PC, and NLR between colorectal cancer group and adenomatous polyp group; (B) comparison of PC, PLR, and SII between colorectal cancer group and adenomatous polyp group.
Figure 2.
Figure 2.
The correlation analysis among inflammation-related indexes and significant factors.
Figure 3.
Figure 3.
Nomogram model. (A) A nomogram composed of inflammation-related indicators; (B) A nomogram composed of CEA; (C) A nomogram composed of inflammation-related indicators and CEA.
Figure 4.
Figure 4.
ROC curves of inflammatory markers and CEA.
Figure 5.
Figure 5.
ROC curve of multivariate analysis of stage I colorectal cancer group and adenomatous polyp group.
See this image and copyright information in PMC

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