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. 1986 Jul;88(3):497-9.
doi: 10.1111/j.1476-5381.1986.tb10228.x.

Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism

W D Miner, G J Sanger

Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism

W D Miner et al. Br J Pharmacol. 1986 Jul.

Abstract

MDL 72222, the selective 5-hydroxytryptamine (5-HT) M-receptor antagonist, prevented or reduced cisplatin-induced emesis in ferrets. It is suggested that cisplatin-induced, and possibly other cytotoxic drug-induced vomiting may involve a 5-HT M-receptor mechanism.

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