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. 2023 Sep:169:105603.
doi: 10.1016/j.fitote.2023.105603. Epub 2023 Jul 6.

Steroidal constituents from Solanum nigrum

Shi-Wei Li  1 , Yu-Heng Zhao  1 , Wen-Ke Gao  1 , Li-Hua Zhang  1 , Hai-Yang Yu  1 , Hong-Hua Wu  2
Affiliations

Steroidal constituents from Solanum nigrum

Shi-Wei Li et al. Fitoterapia. 2023 Sep.

Abstract

Three previously undescribed steroidal constituents including two sterols (1-2) and one pregnane-type steroidal glycoside (6), along with nineteen known ones (3-5, 7-22), were isolated from the 80% alcohol extraction of Solanum nigrum L. Their structures and the absolute configurations were established by analysis of the extensive spectroscopic data (1H/13 NMR, 1H1H COSY, HSQC, HMBC, and NOESY), and/or by comparisons of the experimental electronic circular dichroism (ECD) spectra with those calculated ones by TDDFT method. Further, a MTT assay was applied to demonstrate that compounds 1-4, 6-12, 18, and 22 exhibited significant cytotoxic activities against SW480 cells, and compounds 1-4, 6-14, and 16-22 showed significant cytotoxic activities against Hep3B cells.

Keywords: Cytotoxic activity; Pregnane-type steroidal glycoside; Solanaceae; Solanum nigrum L.; Sterol.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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