Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jul 30;379(1):171-5.
doi: 10.1016/0006-8993(86)90272-6.

Propressophysin is present in neurones at multiple sites in Wistar and homozygous Brattleboro rat brain

F W van Leeuwen, R Caffé, P J van der Sluis, A A Sluiter, T P van der Woude, N G Seidah, M Chrétien

Propressophysin is present in neurones at multiple sites in Wistar and homozygous Brattleboro rat brain

F W van Leeuwen et al. Brain Res. .

Abstract

Vasopressin (VP) is synthesized as propressophysin, containing also neurophysin (NP) and C-terminal glycopeptide (CPP), within the hypothalamo-neurohypophyseal system (HNS). Recently, VP and NP-immunoreactive cells were demonstrated in other rat brain nuclei. Here we report CPP immunoreactivity in perikarya in these nuclei. Within the homozygous Brattleboro rat, known to be deficient in neuronal VP production, no CPP immunoreactivity was seen in these nuclei. However, intense VP and CPP immunoreactivity was present in solitary cells (52.2 +/- 3.3 per rat) and fibres within the HNS.

PubMed Disclaimer

LinkOut - more resources