Chronic Myeloid Leukemia in Children and Adolescents

Abstract

Acute leukemia is the most common malignancy in childhood, while chronic myeloid leukemia is rare, accounting for only 2% to 3% of all leukemia in childhood and 9% in adolescents, with an annual incidence of 1 and 2.2 cases per million in the two groups. The goal in Pediatrics is remission and cure with tyrosine kinase inhibitors (TKIs) and monitoring closely for long-term effects of TKI use.

Keywords: BCR–ABL1 fusion t(9:22); Chronic myeloid leukemia (CML); Compliance; Leukocytosis; Monitoring; Splenomegaly; Tyrosine kinase inhibitor (TKI).