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Review
. 2023 Jul 8;9(1):28.
doi: 10.1038/s41405-023-00147-7.

Roles of extracellular adenosine triphosphate on the functions of periodontal ligament cells

Maythwe Kyawsoewin  1   2 , Jeeranan Manokawinchoke  1   2 , Worachat Namangkalakul  1   2 , Hiroshi Egusa  3   4 , Phoonsuk Limraksasin  5   6   7 , Thanaphum Osathanon  1   2
Affiliations
Review

Roles of extracellular adenosine triphosphate on the functions of periodontal ligament cells

Maythwe Kyawsoewin et al. BDJ Open. .

Abstract

Objective: Adenosine triphosphate (ATP) is an essential nucleotide that is normally present in both intracellular and extracellular compartments. Extracellular ATP (eATP) has a pivotal role in both physiological and pathological processes of periodontal ligament tissues. Here, this review aimed to explore the various functions of eATP that are involved in the control of behaviours and functions of periodontal ligament cells.

Methods: To identify the included publications for review, the articles were searched in PubMed (MEDLINE) and SCOPUS with the keywords of adenosine triphosphate and periodontal ligament cells. Thirteen publications were used as the main publications for discussion in the present review.

Results: eATP has been implicated as a potent stimulator for inflammation initiation in periodontal tissues. It also plays a role in proliferation, differentiation, remodelling, and immunosuppressive functions of periodontal ligament cells. Yet, eATP has diverse functions in regulating periodontal tissue homeostasis and regeneration.

Conclusion: eATP may provide a new prospect for periodontal tissue healing as well as treatment of periodontal disease especially periodontitis. It may be utilized as a useful therapeutic tool for future periodontal regeneration therapy.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Flow chart illustrating the article selection.
Articles are selected for this review by using keywords; adenosine triphosphate (ATP) and periodontal ligament cells (PDLCs).
Fig. 2
Fig. 2. Effects of adenosine triphosphate on the functions of periodontal ligament cells.
This figure summarized the effects of eATP-different P2 receptor signalling pathway in mechanically stimulated PDLCs (Created with BioRender.com).
See this image and copyright information in PMC

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