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Comment
. 2023 Aug;44(8):574-576.
doi: 10.1016/j.it.2023.06.008. Epub 2023 Jul 7.

NLRP12 drives PANoptosis in response to heme

Fiona D R Henkel  1 , Luke A J O'Neill  2
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NLRP12 drives PANoptosis in response to heme

Fiona D R Henkel et al. Trends Immunol. 2023 Aug.

Abstract

PANoptosomes are large cell death-inducing complexes that drive a type of cell death called PANoptosis during infection and inflammation. Sundaram and colleagues recently identified NLRP12 as a PANoptosome that induces PANoptosis in response to heme, TNF, and pathogen-associated molecular patterns (PAMPs), indicating a role for NLRP12 in hemolytic and inflammatory diseases.

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Conflict of interest statement

Declaration of interests None declared by authors.

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