Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep;26(9):1737-1744.
doi: 10.1111/1756-185X.14805. Epub 2023 Jul 9.

Chinese Registry of Psoriatic Arthritis (CREPAR): I. Clinical characteristics of Chinese patients with psoriatic arthritis

Chaofan Lu  1 , Fan Yang  1 , Huilan Liu  1 , Lei Dou  2 , Yanhong Wang  3 , Hongbin Li  4 , Xinwang Duan  5 , Lijun Wu  6 , Yongfu Wang  7 , Xiuying Zhang  8 , Jian Xu  9 , Jinmei Su  1 , Dong Xu  1 , Jiuliang Zhao  1 , Qingjun Wu  1 , Mengtao Li  1 , Xiaomei Leng  1 , Xiaofeng Zeng  1 ; CREPAR co-authors
Affiliations

Chinese Registry of Psoriatic Arthritis (CREPAR): I. Clinical characteristics of Chinese patients with psoriatic arthritis

Chaofan Lu et al. Int J Rheum Dis. 2023 Sep.

Abstract

Aim: To describe the clinical characteristics of Chinese patients with psoriatic arthritis (PsA) using the data recorded in the Chinese Registry of Psoriatic Arthritis (CREPAR).

Methods: This is a cross-sectional study based on the CREPAR registry, which is a prospective registry founded in December 2018. Data regarding clinical characteristics and treatment of patients were collected during every visit. Data recorded at enrollment were extracted, analyzed, and compared with data in other registries or cohorts.

Results: A total of 1074 patients were registered from December 2018 to June 2021. Of these, 929 (86.5%) patients had a history of peripheral arthritis, and 844 patients (78.6%) had peripheral arthritis at enrollment, of which polyarthritis is the most common subtype. Axial involvement was present in 39.9% of patients, and 50 (4.7%) patients had axial involvement only. More than half of the patients (55.4%) had at least two musculoskeletal presentations at enrollment. The prevalence of low disease activity and remission according to DAPSA were 26.4% and 6.8%, respectively. Conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and biological DMARDs were used in 64.9% and 29.1% of patients, respectively. Among patients with different musculoskeletal presentations, patients with dactylitis had the highest proportion of nonsteroidal anti-inflammatory and csDMARD use. The proportion of patients receiving bDMARDs was highest in axial PsA.

Conclusion: The CREPAR registry has provided information on Chinese patients with PsA. Compared with data in other registries or cohorts, the disease activity of patients in CREPAR was higher, and the proportion of bDMARD use was lower.

Keywords: arthritis, psoriatic; clinical features; cohort studies; multicenter study; registries.

PubMed Disclaimer

References

REFERENCES

    1. FitzGerald O, Ogdie A, Chandran V, et al. Psoriatic arthritis. Nat Rev Dis Primers. 2021;7(1):59.
    1. Li R, Sun J, Ren LM, et al. Epidemiology of eight common rheumatic diseases in China: a large-scale cross-sectional survey in Beijing. Rheumatology (Oxford). 2012;51(4):721-729.
    1. Zeng QY, Chen R, Darmawan J, et al. Rheumatic diseases in China. Arthritis Res Ther. 2008;10(1):R17.
    1. Mease PJ, Etzel CJ, Huster WJ, et al. Understanding the association between skin involvement and joint activity in patients with psoriatic arthritis: experience from the Corrona registry. RMD Open. 2019;5(1):e000867.
    1. Bilgin E, Aydin SZ, Tinazzi I, et al. Disease characteristics of psoriatic arthritis patients may differ according to age at psoriasis onset: cross-sectional data from the psoriatic arthritis-international database. Clin Exp Rheumatol. 2021;39(3):532-536.

Substances