Flow cytometric analysis of adrenal cortical tumor DNA. Relationship between cellular DNA and histopathologic classification
- PMID: 3742468
- DOI: 10.1002/1097-0142(19861001)58:7<1499::aid-cncr2820580721>3.0.co;2-v
Flow cytometric analysis of adrenal cortical tumor DNA. Relationship between cellular DNA and histopathologic classification
Abstract
Nuclear DNA contents of 22 paraffin-embedded adrenal cortical tumors (16 adenomas and 6 carcinomas) were determined by flow cytometric analysis. While all of the sixteen adenomas had a diploid pattern, 83.3% (5/6) of the carcinomas were aneuploid. Three of the six patients with carcinomas (50%) developed metastases and died of their disease; all had aneuploid tumors. The three living patients with carcinoma included two children, with aneuploid tumors, and one adult, with a diploid tumor. Large tumor size correlated with aneuploidy. This study indicated that flow cytometric analysis of nuclear DNA content complements conventional histopathologic methods in the diagnosis of malignancy in adrenal cortical tumors. It may also prove to be a valuable tool in predicting the prognosis of patients with adrenal cortical carcinomas.
Similar articles
-
Cellular DNA profiles of benign and malignant adrenocortical tumors.Am J Surg Pathol. 1990 Oct;14(10):948-55. doi: 10.1097/00000478-199010000-00008. Am J Surg Pathol. 1990. PMID: 2403197
-
Relationship between flow cytometric DNA ploidy and nuclear grade with endocrine dysfunction in adrenal cortical adenomas.Urology. 2000 Aug 1;56(2):337-41. doi: 10.1016/s0090-4295(00)00568-9. Urology. 2000. PMID: 10925119
-
Hürthle cell tumors of the thyroid. A flow cytometric DNA analysis.Arch Otolaryngol Head Neck Surg. 1988 May;114(5):520-1. doi: 10.1001/archotol.1988.01860170050016. Arch Otolaryngol Head Neck Surg. 1988. PMID: 3355687
-
New developments in the pathologic diagnosis of adrenal cortical neoplasms. A review.Am J Clin Pathol. 1992 Jan;97(1):73-83. doi: 10.1093/ajcp/97.1.73. Am J Clin Pathol. 1992. PMID: 1728867 Review.
-
Assessment of malignancy in adrenal cortical tumors.Endocr Pathol. 2006 Summer;17(2):131-6. doi: 10.1385/ep:17:2:131. Endocr Pathol. 2006. PMID: 17159245 Review.
Cited by
-
Nuclear DNA patterns in adrenal cortex proliferative lesions.Virchows Arch A Pathol Anat Histopathol. 1993;423(5):323-8. doi: 10.1007/BF01607143. Virchows Arch A Pathol Anat Histopathol. 1993. PMID: 8116223
-
Adrenocortical carcinoma: a literature review.Transl Cancer Res. 2020 Feb;9(2):1253-1264. doi: 10.21037/tcr.2019.12.28. Transl Cancer Res. 2020. PMID: 35117470 Free PMC article. Review.
-
Flow cytometric DNA analysis of parathyroid glands. Relationship between nuclear DNA and pathologic classifications.Am J Pathol. 1987 Aug;128(2):338-44. Am J Pathol. 1987. PMID: 3618729 Free PMC article.
-
Adrenocortical carcinoma.Endocr Rev. 2014 Apr;35(2):282-326. doi: 10.1210/er.2013-1029. Epub 2013 Dec 20. Endocr Rev. 2014. PMID: 24423978 Free PMC article. Review.
-
Survival rates and prognostic factors in adrenocortical carcinoma.World J Surg. 1992 Jul-Aug;16(4):753-8. doi: 10.1007/BF02067377. World J Surg. 1992. PMID: 1413845