Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-23-50/coif). HA was supported by the Clínico Junior 2019 scholarship from the AECC (CLJUN19010ARAS). He has received honoraria for advisory roles from Astra Zeneca, for clinical trial coordination from Ferrer Farma, and accommodation/travel expenses by Takeda, MSD and Angelini Pharma. RV reports that she received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from ROCHE, AMGEM, MERCK, MSD, Lilly, Organon, and BAYER, and received support for attending meetings and/or travel from MSD, MERCK, and Lilly, and serves on a Data Safety Monitoring Board or Advisory Board of Novartis, and takes a leadership or fiduciary role in other board, society, committee or advocacy group, paid or unpaid of AECC, SEOM, and ECO. MA has received honoraria for consultancy/advisory from BMS, MSD and Servier; and received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events for speaking issues from Amgen, BMS, Lilly, MSD, Roche and Servier. The other authors have no conflicts of interest to declare.