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. 2022 Dec 29;15(2):9631.
doi: 10.4081/dr.2023.9631. eCollection 2023 Jun 7.

A case of chronic granulomatous disease and acne: is isotretinoin a safe treatment?

Marco Brusasco  1 , Claudio Feliciani  1 , Maria Beatrice de Felici Del Giudice  1
Affiliations

A case of chronic granulomatous disease and acne: is isotretinoin a safe treatment?

Marco Brusasco et al. Dermatol Reports. .

Abstract

We report the case of a patient with chronic granulomatous disease and acne treated with isotretinoin, who developed a diffuse staphylococcal skin infection during the therapy. Chronic granulomatous disease is a rare genetic disorder characterized by an altered innate immunity with an increased risk of potentially lethal bacterial and fungal infections. Although chronic granulomatous disease is rare, acne is a common manifestation in these patients, but there are no data about the gold standard therapy.

Keywords: acne vulgaris; acneiform eruption; chronic granulomatous disease; isotretinoin; staphylococcal skin infection.

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Figures

Figure 1.
Figure 1.
Acneiform rash at the beginning (a, b) and after ten weeks of therapy with isotretinoin (c, d); diffuse furuncles and abscess after three months of therapy (e, f).
See this image and copyright information in PMC

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