Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2023 Nov 1;37(13):2007-2013.
doi: 10.1097/QAD.0000000000003645. Epub 2023 Jul 7.

Updated mortality and causes of death in 2020-2021 in people with HIV: a multicenter study in France

Pierre Sellier  1 , Guylaine Alexandre-Castor  2 , Alexandre Brun  2 , Gwenn Hamet  2 , Olivier Bouchaud  3 , Pierre Leroy  4 , Sylvain Diamantis  4 , Amélie Chabrol  5 , Moïse Machado  6 , Marie-Anne Bouldouyre  7 , Nathalie De Castro  1 , Willy Rozenbaum  2 , Jean-Michel Molina  1 ; Commission Recherche Clinique du COREVIH Ile-de-France Est
Affiliations
Multicenter Study

Updated mortality and causes of death in 2020-2021 in people with HIV: a multicenter study in France

Pierre Sellier et al. AIDS. .

Abstract

Objective: The aim of this study was to assess updated mortality and causes of death in people with HIV (PWH) in France.

Design and methods: We analyzed all deaths in PWH followed up between January 1, 2020, and December 31, 2021, in 11 hospitals in the Paris region. We described the characteristics and causes of death among deceased PWH, and evaluated the incidence of mortality and associated risk factors using a multivariate logistic regression.

Results: Of the 12 942 patients followed in 2020--2021, 202 deaths occurred. Mean annual incidence of death [95% confidence interval (95% CI)] was 7.8 per 1000 PWH (6.3-9.5). Forty-seven patients (23%) died from non-AIDS nonviral hepatitis (NANH)-related malignancies, 38 (19%) from non-AIDS infections (including 21 cases of COVID-19), 20 (10%) from AIDS, 19 (9%) from cardiovascular diseases (CVD), 17 (8.4%) from other causes, six (3%) from liver diseases, and five (2.5%) from suicides/violent deaths. The cause of death was unknown in 50 (24.7%) patients. Risks factors for death were age [adjusted odds ratio (aOR) 1.93; 1.66-2.25 by additional decade), AIDS history (2.23; 1.61-3.09), low CD4 + cell count (1.95; 1.36-2.78 for 200-500 cells/μl and 5.76; 3.65-9.08 for ≤200 versus > 500 cells/μl), and viral load more than 50 copies/ml (2.03; 1.33-3.08), both at last visit.

Conclusion: NANH malignancies remained in 2020-2021 the first cause of death. COVID-19 accounted for more than half of the mortality related to non-AIDS infections over the period. Aging, AIDS history, and a poorer viro-immunological control were associated with death.

PubMed Disclaimer

References

    1. Mocroft A, Vella S, Benfield TL, Chiesi A, Miller V, Gargalianos P, et al. Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group . Lancet 1998; 352:1725–1730.
    1. Trickey A, Sabin CA, Burkholder G, Crane H, d’Arminio Monforte A, Egger M, et al. Life expectancy after 2015 of adults with HIV on long-term antiretroviral therapy in Europe and North America: a collaborative analysis of cohort studies . Lancet HIV 2023; 10:e295–e307.
    1. Samji H, Cescon A, Hogg RS, Modur SP, Althoff KN, Buchacz K, et al. North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA. Closing the gap: increases in life expectancy among treated HIV-positive individuals in the United States and Canada . PLoS One 2013; 8:e81355.
    1. Gueler A, Moser A, Calmy A, Günthard HF, Bernasconi E, Furrer H, et al. Swiss HIV Cohort Study, Swiss National Cohort. Life expectancy in HIV-positive persons in Switzerland: matched comparison with general population . AIDS 2017; 31:427–436.
    1. Marty L, Diawara Y, Rachas A, Grabar S, Costagliola D, Supervie V. Projection of age of individuals living with HIV and time since ART initiation in 2030: estimates for France . J Int AIDS Soc 2022; 25: (Suppl 4): e25986.

Publication types