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. 2023 Sep;122(9):2147-2154.
doi: 10.1007/s00436-023-07913-4. Epub 2023 Jul 10.

Sexual dimorphism in the murine model of extraparenchymal neurocysticercosis

Carlos Alexandre Aguiar Moreira  1 , Luis Henrique Vallesquino Murayama  1 , Tatiane de Camargo Martins  1 , Vinicius Tadeu Oliveira  1 , Diego Generoso  1 , Vania Maria de Vasconcelos Machado  2 , Sabrina Setembre Batah  3 , Alexandre Todorovic Fabro  3 , Rodrigo Bazan  1 , Marco Antônio Zanini  1 , Edda Sciutto  4 , Agnès Fleury  4   5 , Pedro Tadao Hamamoto Filho  6
Affiliations

Sexual dimorphism in the murine model of extraparenchymal neurocysticercosis

Carlos Alexandre Aguiar Moreira et al. Parasitol Res. 2023 Sep.

Abstract

Neurocysticercosis is a heterogeneous disease, and the patient's sex seems to play a role in this heterogeneity. Hosts' sexual dimorphism in cysticercosis has been largely explored in the murine model of intraperitoneal Taenia crassiceps cysticercosis. In this study, we investigated the sexual dimorphism of inflammatory responses in a rat model of extraparenchymal neurocysticercosis caused by T. crassiceps. T. crassiceps cysticerci were inoculated in the subarachnoid space of Wistar rats (25 females, 22 males). Ninety days later, the rats were euthanized for histologic, immunohistochemistry, and cytokines studies. Ten animals also underwent a 7-T magnetic resonance imaging (MRI). Female rats presented a higher concentration of immune cells in the arachnoid-brain interface, reactive astrogliosis in the periventricular region, in situ pro-inflammatory cytokine (interleukin [IL]-6) and anti-inflammatory cytokine (IL-10), and more intense hydrocephalus on MRI than males. Intracranial hypertension signals were not observed during the observational period. Overall, these results suggest sexual dimorphism in the intracranial inflammatory response that accompanied T. crassiceps extraparenchymal neurocysticercosis.

Keywords: Hydrocephalus; Inflammation; Neurocysticercosis; Sex dimorphism; Taenia crassiceps.

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