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. 2025 Jan-Feb;48(1):E29-E38.
doi: 10.1097/NCC.0000000000001269. Epub 2023 Jul 11.

Factors Related to Functional Capacity Deterioration in Surgical Lung Cancer Patients: A Systematic Review

Xinyi Xu  1 , Xiaohang Liu, Mu-Hsing Ho, Pui Hing Chau, Denise Shuk Ting Cheung, Chia-Chin Lin
Affiliations

Factors Related to Functional Capacity Deterioration in Surgical Lung Cancer Patients: A Systematic Review

Xinyi Xu et al. Cancer Nurs. 2025 Jan-Feb.

Abstract

Background: A decline in functional capacity is anticipated after lung resection. However, the factors related to functional capacity deterioration in surgical lung cancer patients have not been systematically reviewed.

Objective: To investigate the factors related to functional capacity deterioration and the trajectory of functional capacity after lung cancer surgery.

Methods: PubMed, CINAHL, Scopus, and SPORTDiscus were searched between January 2010 and July 2022. Two reviewers conducted a critical appraisal of individual sources. Twenty-one studies met the inclusion criteria.

Results: This review presents evidence for risk factors related to functional capacity deterioration after lung cancer surgery, including patient characteristics (age), preoperative clinical factors (vital capacity, quadriceps force, B-type natriuretic peptide level), surgery-related factors (surgical procedure, duration of chest tube drainage, postoperative complications), and postoperative clinical factor (C-reactive protein level). Most patients had a significant decline in functional capacity in the short term (≤1 month from surgery). In the medium term (1 to ≤6 months from surgery), although the functional capacity did not return to the preoperative level, the decline became insignificant.

Conclusions: This study is the first to review factors related to functional capacity in lung cancer patients. The findings can help clinicians to better identify patients at risk of functional capacity decline and allocate clinical resources more efficiently.

Implications for practice: The risk factors related to the functional capacity decline in surgical lung cancer patients should be evaluated routinely during perioperative nursing assessments. Preoperative and postoperative nursing interventions can potentially improve modifiable risk factors and prevent functional capacity deterioration.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

References

    1. Bade BC, dela Cruz CS. Lung cancer 2020: epidemiology, etiology, and prevention. Clin Chest Med . 2020;41(1):1–24.
    1. Blandin Knight S, Crosbie PA, Balata H, Chudziak J, Hussell T, Dive C. Progress and prospects of early detection in lung cancer. Open Biol . 2017;7(9):170070.
    1. Arena R, Myers J, Williams MA, et al. Assessment of functional capacity in clinical and research settings: a scientific statement from the American Heart Association Committee on Exercise, Rehabilitation, and Prevention of the Council on Clinical Cardiology and the Council on Cardiovascular Nursing. Circulation . 2007;116(3):329–343.
    1. Lee H, Kim HK, Kang D, et al. Prognostic value of 6-min walk test to predict postoperative cardiopulmonary complications in patients with non–small cell lung cancer. Chest . 2020;157(6):1665–1673.
    1. Jones LW, Watson D, Herndon JE 2nd, et al. Peak oxygen consumption and long-term all-cause mortality in nonsmall cell lung cancer. Cancer . 2010;116(20):4825–4832.

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