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. 2023 Jul 31;46(7):414-416.
doi: 10.14348/molcells.2023.0060. Epub 2023 Jul 5.

Disulfidptosis: Disulfide Stress Mediates a Novel Cell Death Pathway via Actin Cytoskeletal Vulnerability

Dongpu Shao  1 , Lei Shi  1 , Honglei Ji  1
Affiliations

Disulfidptosis: Disulfide Stress Mediates a Novel Cell Death Pathway via Actin Cytoskeletal Vulnerability

Dongpu Shao et al. Mol Cells. .
No abstract available

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Conflict of interest statement

CONFLICT OF INTEREST

The authors have no potential conflicts of interest to disclose.

Figures

None
Schematic illustration of disulfidptosis. Cystine is transported to intracellular compartments by solute carrier family 7 member 11 (SLC7A11). Nicotinamide adenine dinucleotide phosphate (NADPH) is generated in the cytosol through the pentose phosphate pathway (PPP). In the presence of the reducing agent NADPH, one molecule of cystine is reduced to two molecules of cysteine, accompanied by oxidation of NADPH to NADP+. The F-actin cytoskeleton contracts due to aberrant disulfide bonding. Cells can survive if the reduced form of NADPH counteracts the accumulation of intracellular disulfides. Disulfidptosis is induced if the balance between cystine and NADPH/NADP+ is disrupted.
See this image and copyright information in PMC

References

    1. Dixon S.J., Lemberg K.M., Lamprecht M.R., Skouta R., Zaitsev E.M., Gleason C.E., Patel D.N., Bauer A.J., Cantley A.M., Yang W.S., et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–1072. doi: 10.1016/j.cell.2012.03.042. - DOI - PMC - PubMed
    1. Liu X., Nie L., Zhang Y., Yan Y., Wang C., Colic M., Olszewski K., Horbath A., Chen X., Lei G., et al. Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat. Cell Biol. 2023;25:404–414. doi: 10.1038/s41556-023-01091-2. - DOI - PMC - PubMed
    1. Liu X., Olszewski K., Zhang Y., Lim E.W., Shi J., Zhang X., Zhang J., Lee H., Koppula P., Lei G., et al. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat. Cell Biol. 2020;22:476–486. doi: 10.1038/s41556-020-0496-x. - DOI - PMC - PubMed
    1. Tsvetkov P., Coy S., Petrova B., Dreishpoon M., Verma A., Abdusamad M., Rossen J., Joesch-Cohen L., Humeidi R., Spangler R.D., et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022;375:1254–1261. doi: 10.1126/science.abf0529. - DOI - PMC - PubMed

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