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. 2023 Jul 31;46(7):417-419.
doi: 10.14348/molcells.2023.0069. Epub 2023 Jul 10.

Ant-Agonizing Aging without Tradeoffs in Queens

Hanseul Lee  1 , Seung-Jae V Lee  1
Affiliations

Ant-Agonizing Aging without Tradeoffs in Queens

Hanseul Lee et al. Mol Cells. .
No abstract available

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Conflict of interest statement

CONFLICT OF INTEREST

The authors have no potential conflicts of interest to disclose.

Figures

None
Molecular basis of extreme longevity and active reproduction in queen ants. A queen ant lives long and reproduces actively, whereas worker ants are short-lived and sterile. Insulin upregulation in the brain of pseudoqueens, and very likely in queens, activates insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS)–mitogen-activated protein kinase (MAPK) in the fat body and ovary, leading to active reproduction. Insulin from the brain also promotes the secretion of imaginal morphogenesis protein-late 2 (Imp-L2) in the ovary, which inhibits IIS–AKT, consequently promoting longevity.
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