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. 2023 Jul 11;18(7):e0288337.
doi: 10.1371/journal.pone.0288337. eCollection 2023.

Extra-pancreatic manifestations reported in association with pancreatitis; an international survey report

Chinenye R Dike  1   2 , Qin Kiki Sun  3 , Lola Rahib  4 , Megan Golden  4 , Maisam Abu-El-Haija  5   6
Affiliations

Extra-pancreatic manifestations reported in association with pancreatitis; an international survey report

Chinenye R Dike et al. PLoS One. .

Abstract

Background/objectives: Local and systemic manifestations have been reported in association with pancreatitis, anecdotally. However, a systematic collection on the prevalence of each of these symptoms in pancreatitis is lacking. We aimed to determine the prevalence of symptoms and diagnoses reported by a cohort of patients with pancreatitis, refer to as "extra pancreatic manifestation of pancreatitis".

Methods: Cross-sectional study approved by the IRB and administered through a REDCap survey by "Mission: Cure", a nonprofit organization.

Results: Of the 225 respondents analyzed; 89% were adults, 69% females, 89% Caucasians with 74% residing in the USA. 42% of children and 50% of adults reported exocrine pancreatic insufficiency while 8% of children and 26% of adults reported DM. Type 3c DM was reported in all children and 45% of adult DM cases. Children were diagnosed with genetic or hereditary pancreatitis more frequently compared to adults (33.3% versus 8%; p = <0.001). Significantly more symptoms and diagnoses were reported by adults when compared to children including nighttime sweats, bloating, or cramping, greasy or oily stools, feeling cold and GERD with p values of 0.002, 0.006, 0.046, 0.002 and 0.003 respectively.

Conclusions: Adults with pancreatitis frequently report symptoms not known to be associated with pancreatitis. Studies investigating mechanisms for these associated symptoms should be explored.

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Conflict of interest statement

The authors have declared that no competing interests exist

Figures

Fig 1
Fig 1. Participant flow chart.
Fig 2
Fig 2. Map of countries with > 1 participant or survey respondent.
Fig 3
Fig 3
A: Bar chart with top 10 symptoms reported by survey participants. B: Bar chart with top 5 diagnoses reported by survey participants.
See this image and copyright information in PMC

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