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. 2023 Oct;66(10):898-905.
doi: 10.1111/myc.13629. Epub 2023 Jul 11.

Nikkomycin Z for the treatment of experimental sporotrichosis caused by Sporothrix brasiliensis

Vanice Rodrigues Poester  1   2 , Lívia Silveira Munhoz  2 , David A Stevens  3   4 , Aryse Martins Melo  5 , Mariana Rodrigues Trápaga  1   2 , Mariana Martins Flores  6 , David J Larwood  3   7 , Melissa Orzechowski Xavier  1   2
Affiliations

Nikkomycin Z for the treatment of experimental sporotrichosis caused by Sporothrix brasiliensis

Vanice Rodrigues Poester et al. Mycoses. 2023 Oct.

Abstract

Sporotrichosis caused by Sporothrix brasiliensis is a global emergent infectious disease. Due to the scarcity of therapeutic options for fungal diseases, new antifungals are urgently needed. Nikkomycin Z (NikZ) is a future option as an agent against dimorphic fungi. We evaluated NikZ monotherapy and in combination with itraconazole (ITZ; the conventional therapy) in the treatment of experimental sporotrichosis caused by S. brasiliensis in a murine model. Animals were subcutaneously infected, and treated orally for 30 days. The study groups were as follows control (untreated), ITZ group (50 mg/kg/day), and three groups treated with NikZ, two by monotherapy (200 or 400 mg/kg/day), and one combining NikZ (400 mg/kg/day) and ITZ. Efficacy of treatments was evaluated via body weight gain, mortality and fungal burden in tissues. Efficacy was noted in all treatment groups, and the group receiving the drug combination showed even better results than those with monotherapy. Our study shows for the first time the high potential of NikZ to be used in the treatment of sporotrichosis caused by S. brasiliensis.

Keywords: Sporothrix sp.; antifungal; chitin inhibitor; in vivo model; murine model; zoonosis.

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References

REFERENCES

    1. Rodrigues AM, Gonçalves SS, de Carvalho JA, Borba-Santos LP, Rozental S, de Camargo ZP. Current progress on epidemiology, diagnosis, and treatment of sporotrichosis and their future trends. J Fungi. 2022;8(8):776. doi:10.3390/jof8080776
    1. Duarte JMG, Acosta VRW, Viera PMLF, et al. Sporotrichosis transmitted by domestic cat. A family case report. Del Nacional. 2017;9(2):67-76. doi:10.18004/rdn2017.0009.02.067-076
    1. Etchecopaz A, Toscanini MA, Gisbert A, et al. Sporothrix brasiliensis: a review of an emerging south American fungal pathogen, its related disease, presentation and spread in Argentina. J Fungi. 2021;7(3):170. doi:10.3390/jof7030170
    1. Thomson P, González C, Blank O, et al. Sporotrichosis outbreak due to Sporothrix brasiliensis in domestic cats in magallanes, Chile: a ne-health-approach study. J Fungi. 2023;9(2):226. doi:10.3390/jof9020226
    1. Rachman R, Ligaj M, Chinthapalli S, Wani RS. Zoonotic acquisition of cutaneous Sporothrix braziliensis infection in the UK. BMJ Case Rep. 2022;15(5):e248418. doi:10.1136/bcr-2021-248418

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