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Review
. 2023 Jul 3:2023:1099013.
doi: 10.1155/2023/1099013. eCollection 2023.

Clinical Efficacy of Platelet Derivatives in Periodontal Tissue Regeneration: An Umbrella Review

Carlos M Ardila  1 , María Pertuz  2 , Annie Marcela Vivares-Builes  2
Affiliations
Review

Clinical Efficacy of Platelet Derivatives in Periodontal Tissue Regeneration: An Umbrella Review

Carlos M Ardila et al. Int J Dent. .

Abstract

Objectives: This umbrella review aimed to consolidate the best available evidence regarding the clinical efficacy of platelet derivatives in the treatment of periodontal defects associated with periodontitis and in the management of mucogingival deformities.

Materials and methods: The "umbrella review" strategy was used to identify systematic reviews and meta-analyses. The search was performed without language restrictions and updated at the end of February 2023. The PubMed and Scopus databases, together with gray literature, were included in the search.

Results: The search yielded 412 studies. Subsequently, 12 articles were selected for further examination based on relevance. Finally, eight systematic reviews and meta-analyses were assessed. Regarding intrabony defects, in terms of clinical attachment level (CAL) gain, platelet-rich fibrin (PRF) was observed to lead to a statistically significant attachment gain compared to surgical therapy alone. PRF was also found to show greater CAL gain compared to platelet-rich plasma (PRP) and other biomaterials. The parameter probing depth decreased significantly when PRF was used compared to surgical therapy alone (P < 0.05). Similar results were seen when leukocyte- and platelet-rich fibrin (L-PRF) was applied. In terms of radiographic bone fill, both PRF and PRP showed significantly greater bone fill compared to surgical therapy. Regarding the results of periodontal plastic surgery, PRF favored a slight root coverage compared to the coronally displaced flap. This result depended on the number of PRF and L-PRF membranes used, but Emdogain or connective tissue graft produced better results regardless. However, an improvement in the healing of periodontal tissues was reported.

Conclusions: Therapies with platelet derivatives applied to intrabony defects provided superior regenerative results compared to monotherapies, except in the case of root coverage.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of the review's selection method.
See this image and copyright information in PMC

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References

    1. Lang N. P., Mark Bartold P. Periodontal health. Journal of Clinical Periodontology . 2018;45(Suppl 20):S9–S16. doi: 10.1111/jcpe.12936. - DOI - PubMed
    1. Kwon T. H., Lamster I. B., Levin L. Current concepts in the management of periodontitis. International Dental Journal . 2021;71(6):462–476. doi: 10.1111/idj.12630. - DOI - PMC - PubMed
    1. Spahr A., Divnic‐Resnik T. Impact of health and lifestyle food supplements on periodontal tissues and health. Periodontology 2000 . 2022;90(1):146–175. doi: 10.1111/prd.12455. - DOI - PMC - PubMed
    1. Roberts F. A., Darveau R. P. Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis. Periodontology 2000 . 2015;69(1):18–27. doi: 10.1111/prd.12087. - DOI - PMC - PubMed
    1. Prato G. P. P. Mucogingival deformities. Annals of Periodontology . 1999;4(1):98–100. doi: 10.1902/annals.1999.4.1.98. - DOI - PubMed