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Review
. 2023 Dec;170(4):470-482.
doi: 10.1111/imm.13680. Epub 2023 Jul 12.

cAMP responsive element modulator α promotes effector T cells in systemic autoimmune diseases

Emil Carlsson  1 , Taylor Cowell-McGlory  1 , Christian M Hedrich  1   2   3
Affiliations
Free article
Review

cAMP responsive element modulator α promotes effector T cells in systemic autoimmune diseases

Emil Carlsson et al. Immunology. 2023 Dec.
Free article

Abstract

T lymphocytes play a crucial role in adaptive immunity. Dysregulation of T cell-derived inflammatory cytokine expression and loss of self-tolerance promote inflammation and tissue damage in several autoimmune/inflammatory diseases, including systemic lupus erythematosus (SLE) and psoriasis. The transcription factor cAMP responsive element modulator α (CREMα) plays a key role in the regulation of T cell homeostasis. Increased expression of CREMα is a hallmark of the T cell-mediated inflammatory diseases SLE and psoriasis. Notably, CREMα regulates the expression of effector molecules through trans-regulation and/or the co-recruitment of epigenetic modifiers, including DNA methyltransferases (DNMT3a), histone-methyltransferases (G9a) and histone acetyltransferases (p300). Thus, CREMα may be used as a biomarker for disease activity and/or target for future targeted therapeutic interventions.

Keywords: CREM; epigenetics; lymphocyte; psoriasis; psoriatic arthritis; systemic lupus erythematosus.

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References

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