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. 2023 Sep;22(3):501-506.
doi: 10.1007/s42000-023-00466-2. Epub 2023 Jul 12.

Which method is more effective in predicting adult height in pubertal girls treated with gonadotropin-releasing hormone agonist?

Gözde Akın Kağızmanlı  1 , Reyhan Deveci Sevim  2 , Özge Besci  1 , Kübra Yüksek Acinikli  1 , Ayşen Hazal Buran  3 , İbrahim Mert Erbaş  1 , Ece Böber  1 , Korcan Demir  1 , Ahmet Anık  2 , Ayhan Abacı  4
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Which method is more effective in predicting adult height in pubertal girls treated with gonadotropin-releasing hormone agonist?

Gözde Akın Kağızmanlı et al. Hormones (Athens). 2023 Sep.

Abstract

Purpose: The aim of the present study was to determine the efficiency of three different predictive models [Bayley-Pinneau (BP), Roche-Wainer-Thissen (RWT), and Tanner-Whitehouse 2 (TW2)] by comparing their predictions with near-adult height data of girls receiving gonadotropin-releasing hormone agonist (GnRHa) therapy.

Methods: Clinical findings were retrospectively analyzed. Bone ages obtained before treatment were evaluated from left hand and wrist radiographs by three researchers. Predicted adult height (PAH) was calculated using the BP, RWT, and TW2 methods for each patient at the beginning of therapy.

Results: The median age at diagnosis of the 48 patients included in the study was 8.8 (8.9-9.3) years. There was no significant difference between the mean bone ages evaluated separately with the Greulich-Pyle atlas and the TW3-RUS method (p=0.34). Among the PAH methods, only PAH measured by the BP method was very close to and no different from near adult height (NAH) [159.8±6.3 vs. 158.8±9.3 cm. p=0.3; (-0.5±1.1) vs. (-0.7±1.6) standard deviation score, p=0.1]. Accordingly, the BP method was found to be the most accurate prediction tool in girls with puberty treated with GnRHa.

Conclusion: The BP method is more effective at predicting adult height than the RWT and TW2 methods in female patients who will receive GnRHa treatment.

Keywords: Final height; Gonadotropin-releasing hormone agonist; Near-adult height; Precocious puberty; Predicted adult height.

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