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Meta-Analysis
. 2023 Aug;14(4):789-802.
doi: 10.1007/s41999-023-00800-2. Epub 2023 Jul 12.

Prevalence and risk factors of frailty in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis

Li-Cong Yan #  1 , Hong-Yan Lu #  2 , Xiao-Yan Wang  3 , Gang Xiao  4 , Yan Chang  5 , Ping Yuan  1 , Bei Wang  1
Affiliations
Meta-Analysis

Prevalence and risk factors of frailty in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis

Li-Cong Yan et al. Eur Geriatr Med. 2023 Aug.

Abstract

Objective: To systematically review the prevalence and risk factors for frailty in patients with chronic obstructive pulmonary disease (COPD).

Methods: A systematic review and meta-analysis were conducted, and a search of the PubMed, Embase and Web of Science databases was carried out to collect Chinese and English studies on frailty and COPD published up to September 5, 2022.

Results: A total of 38 articles were included for the quantitative analysis after the collected literature was either included or omitted based on pertinent criteria. The results indicated that the estimated overall pooled prevalence of frailty was 36% (95% confidence interval [CI] = 31-41%), and the estimated pre-frailty was 43% (95% CI = 37-49%). A higher age (odds ratio [OR] = 1.04; 95% CI = 1.01-1.06) and higher COPD assessment test (CAT) score (OR = 1.19; 95% CI = 1.12-1.27) were associated with a significantly increased likelihood of frailty in patients with COPD. However, a higher educational attainment (OR = 0.55; 95% CI = 0.43-0.69) and higher income (OR = 0.63; 95% CI = 0.45-0.88) were associated with a significantly reduced risk of frailty in patients with COPD. A total of 17 other risk factors for frailty were identified via qualitative synthesis.

Conclusion: The incidence of frailty in patients with COPD is high, and there are many influencing factors.

Keywords: Chronic obstructive pulmonary disease; Frailty; Meta-analysis; Risk factors.

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Conflict of interest statement

All authors declare that they have no conflicts of interest.

Figures

Fig. 1
Fig. 1
PRISMA flowchart
Fig. 2
Fig. 2
Forest plots of frailty in COPD
Fig. 3
Fig. 3
Sensitivity analyses
Fig. 4
Fig. 4
Funnel plot with pseudo 95% confidence limits
Fig. 5
Fig. 5
Forest plots of pre-frailty in COPD
See this image and copyright information in PMC

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