Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Jul 11;56(7):1431-1433.
doi: 10.1016/j.immuni.2023.06.009.

IL-3 finds its home in the brain

Alice Bertocchi  1 , Stephanie K Dougan  2
Affiliations
Free article
Comment

IL-3 finds its home in the brain

Alice Bertocchi et al. Immunity. .
Free article

Abstract

Interleukin-3 (IL-3) induces emergency hematopoiesis in settings of acute inflammation. In this issue of Immunity, Kiss et al. find that IL-3 derived from astrocytes and CD4+ T cells is a key regulatory cytokine of the central nervous system, and increased IL-3 signaling exacerbates neuroinflammation.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests S.K.D. receives research funding unrelated to this project from Novartis Pharmaceuticals and Bristol-Myers Squibb and is a founder, science advisory board member, and equity holder in Kojin.

Comment on

  • Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.
    Kiss MG, Mindur JE, Yates AG, Lee D, Fullard JF, Anzai A, Poller WC, Christie KA, Iwamoto Y, Roudko V, Downey J, Chan CT, Huynh P, Janssen H, Ntranos A, Hoffmann JD, Jacob W, Goswami S, Singh S, Leppert D, Kuhle J, Kim-Schulze S, Nahrendorf M, Kleinstiver BP, Probert F, Roussos P, Swirski FK, McAlpine CS. Kiss MG, et al. Immunity. 2023 Jul 11;56(7):1502-1514.e8. doi: 10.1016/j.immuni.2023.04.013. Epub 2023 May 8. Immunity. 2023. PMID: 37160117 Free PMC article.

LinkOut - more resources