Putting a stamp on plasma cells' age certificate
- PMID: 37437534
- DOI: 10.1016/j.immuni.2023.06.015
Putting a stamp on plasma cells' age certificate
Abstract
Long-lived plasma cells (LLPCs) play a central role in protective immunity after vaccination and infection. In this issue of Immunity, Robinson, Ding, et al. utilize a timestamping approach to fate map and characterize the LLPC compartment and demonstrate that PC longevity in the bone marrow is independent of competition for niches with newly generated incoming PCs.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan.Immunity. 2023 Jul 11;56(7):1596-1612.e4. doi: 10.1016/j.immuni.2023.04.015. Epub 2023 May 9. Immunity. 2023. PMID: 37164016
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