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Comment
. 2023 Jul 11;56(7):1437-1439.
doi: 10.1016/j.immuni.2023.06.014.

Th1-like Treg cells are dressed to suppress anti-tumor immunity

Delaney E Ramirez  1 , Mary Jo Turk  2
Affiliations
Comment

Th1-like Treg cells are dressed to suppress anti-tumor immunity

Delaney E Ramirez et al. Immunity. .

Abstract

Mechanisms of Th1-like Treg suppression are unknown in cancer. Two studies in Immunity by Ayala et al. and Zagorulya et al. demonstrate that Th1-like Treg cells interact with type 1 dendritic cells in tumors and draining lymph nodes to potently suppress anti-tumor immunity.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1.
Figure 1.. Th1-like Treg Cells in the tumor-draining lymph node (TDLN) and the tumor microenvironment (TME) suppress anti-tumor immunity
(Left) Th1-like Treg cells interact with and suppress DC1s, downregulating costimulatory molecule expression and IL-12 production, and reducing CD8+ T cell activation. (Right) CXCR3 expression on Treg cells is crucial for their suppression of tumor control. CXCR3 is also important for Treg cell accumulation in the TME where they interact with CXCL9-secreting DC1s and results in decreased DC1 cross-presentation.
See this image and copyright information in PMC

Comment on

References

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