Comment
doi: 10.1016/j.cmet.2023.06.001.
Sex- and timing-specific effects of fasting and caloric restriction
Affiliations
- PMID: 37437541
- DOI: 10.1016/j.cmet.2023.06.001
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Comment
Sex- and timing-specific effects of fasting and caloric restriction
Cell Metab.
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Abstract
Optimizing food quantity and fasting time may improve health and lifespan. We summarize emerging knowledge on sex, age, and circadian timing as important determinants for the efficacy of dietary interventions and highlight results from Duregon et al. pointing to a favorable combination of caloric restriction (CR) and fasting in aged female mice.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests F.M. is a scientific cofounder of Samsara Therapeutics, a company that develops new pharmacological autophagy inducers. F.M. has equity interests in and is an advisor of The Longevity Labs (TLL).
Comment on
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Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice.Cell Metab. 2023 Jul 11;35(7):1179-1194.e5. doi: 10.1016/j.cmet.2023.05.003. Cell Metab. 2023. PMID: 37437544 Free PMC article.