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Comment
. 2023 Jul 11;35(7):1093-1095.
doi: 10.1016/j.cmet.2023.06.006.

The glucose-to-acetate metabolic flux that drives endothelial-to-mesenchymal transition via TGF-β signaling

Cristina Arce Recatalá  1 , Massimo M Santoro  2
Affiliations
Free article
Comment

The glucose-to-acetate metabolic flux that drives endothelial-to-mesenchymal transition via TGF-β signaling

Cristina Arce Recatalá et al. Cell Metab. .
Free article

Abstract

The metabolic mechanisms supporting the process of endothelial-to-mesenchymal transition (EndMT) remain largely unknown. Here, Zhu et al. describe a novel role for acetate and ACC2 in regulating EndMT and atherosclerosis via modulation of the TGF-β signaling. This study sheds light on the role of glucose-derived metabolites that drive endothelial pathophysiology.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Acetate controls endothelial-to-mesenchymal transition.
    Zhu X, Wang Y, Soaita I, Lee HW, Bae H, Boutagy N, Bostwick A, Zhang RM, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder NW, Yu L, Arany Z, Simons M. Zhu X, et al. Cell Metab. 2023 Jul 11;35(7):1163-1178.e10. doi: 10.1016/j.cmet.2023.05.010. Epub 2023 Jun 15. Cell Metab. 2023. PMID: 37327791 Free PMC article.

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